NDLI: Elevated carbohydrate antigen 125 levels in patients with aortic stenosis: relation to clinical severity and echocardiographic parameters.

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Elevated carbohydrate antigen 125 levels in patients with aortic stenosis: relation to clinical severity and echocardiographic parameters.

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Year: 2012 Volume: 40 Issue: 3

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Elevated carbohydrate antigen 125 levels in patients with aortic stenosis: relation to clinical severity and echocardiographic parameters.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Varol, Ercan Yücel, Habil Arslan, Akif Ozaydin, Mehmet Erdogan, Dogan Dogan, Abdullah
Description	Country affiliation: Turkey Author Affiliation: Varol E ( Department of Cardiology, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey. drercanvarol@yahoo.com)
Abstract	OBJECTIVES: Carbohydrate antigen 125 (CA 125), known as a tumor marker for ovarian cancer, has been reported to increase in relation to disease severity in heart failure patients with systolic dysfunction. Aortic stenosis (AS) has a wide clinical spectrum that often includes heart failure symptoms. The purpose of the present study is to evaluate the serum levels of CA 125 in patients with AS and its relation to clinical severity and echocardiographic parameters. STUDY DESIGN: The study group consisted of 42 patients (20 males, 22 females, mean age 62.5 ± 14.9 years) with AS and 35 healthy controls (17 men, 18 women; mean age 59.0 ± 9.1 years). All patients and control subjects underwent chest X-ray and echocardiographic evaluation. We measured serum CA 125 values in patients with AS and control subjects. RESULTS: The median (interquartile range) CA 125 level was significantly higher among AS patients than in the control group in covariate analysis (9.4 [2.5-38.1] vs. 6.8 [4.4-13.9] U/ml respectively; p=0.001). Spearman correlation analysis in the whole group indicated that CA 125 was positively correlated with aortic mean gradient (p=0.007, r=0.30) and creatinine levels (p=0.02, r=0.26). CONCLUSION: We found that CA 125 levels were elevated in patients with AS and were correlated with mean gradient and creatinine levels.
File Format	HTM / HTML
ISSN	10165169
e-ISSN	13084488
Journal	Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology
Issue Number	4
Volume Number	40
Language	English
Publisher	Türk Kardiyoloji Derneği
Publisher Date	2012-06-01
Publisher Place	Turkey
Access Restriction	Open
Subject Keyword	Discipline Cardiology Aortic Valve Stenosis Diagnosis Ca-125 Antigen Blood Analysis Of Variance Case-control Studies Echocardiography Severity Of Illness Index
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

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