NDLI: Anaphylaxis induced by ingestion of raw garlic.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ma, Shikun Yin, Jia
Description	Country affiliation: China Author Affiliation: Ma S ( Department of Allergy, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.)
Abstract	Patients allergic to garlic often present dermatitis, rhinitis, asthma, and urticaria after ingestion of garlic, contact with garlic, or exposure to garlic dust. Garlic-related anaphylaxis is rare, and the impact of heating on garlic allergens is not very clear. We report a case of anaphylaxis induced by ingestion of raw rather than cooked garlic with manifestations different from previous reports, and we hypothesized that heating could reduce the allergenicity of garlic. Serum total immunoglobulin E (IgE) and specific IgE were tested using the Phadia CAP System FEIA (Phadia, Uppsala, Sweden). Protein extracts from raw and cooked garlic were analyzed by sodium dodecylsulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot. Serum-specific IgE for garlic was 8.16 kUA/L. IgE banding proteins could only be detected in raw garlic extract, because allergens in garlic were mostly degraded into small fragments after heating, as shown in SDS-PAGE profile. In conclusion, raw garlic could induce life-threatening anaphylaxis. However, most of its allergens are heat labile, and patients allergic to garlic might tolerate the cooked one well.
File Format	HTM / HTML
ISSN	15353141
Issue Number	8
Volume Number	9
e-ISSN	15567125
Journal	Foodborne Pathogens and Disease
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2012-08-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Microbiology Discipline Parasitology Discipline Nutritional Sciences Anaphylaxis Immunology Food Hypersensitivity Physiopathology Garlic Adverse Effects Adult Allergens Analysis Diagnosis Blotting, Western Cooking Electrophoresis, Polyacrylamide Gel Chemistry Humans Immunoglobulin E Blood Male Sodium Dodecyl Sulfate Metabolism Case Reports Journal Article
Content Type	Text
Resource Type	Case study Article
Subject	Animal Science and Zoology Microbiology Applied Microbiology and Biotechnology Food Science

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