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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pu, Run Geng, Xiang-nan Yu, Fei Liang, Hui-gang Shi, Lu-wen |
| Description | Country affiliation: China Author Affiliation: Pu R ( Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China.) |
| Abstract | OBJECTIVE: To perform meta-analyses evaluating the efficacy of adding Liuwei Dihuang Pills (, LDP) to Western medicine in improving treatment outcomes for type 2 diabetes. METHODS: Medline, PubMed, Cochrane Library, and Chinese databases, including the Chinese National Knowledge Infrastructure were searched to identify eligible studies; i.e., if the study involved a randomized clinical trial in which the experimental group combined LDP with Western drugs and the control group used the corresponding Western drugs alone to treat type 2 diabetes. Outcomes were measured in terms of fasting blood glucose (FBG), postprandial blood glucose (2hPG) and HbA1c level. Efficacy was also measured by using control and response rates. The combined odds ratio (OR), mean difference (MD), and 95% confidence intervals (95% CI) were calculated. RESULTS: Studies included in the analysis were less adequate than expected in terms of methodological quality. A total of 1,609 patients from 18 studies were included. We found that adding LDP can lower patients' FBG (MD=0.54 mmol/L, 95% CI [0.15, 0.93], P=0.007), 2hPG (MD=1.05 mmol/L, 95% CI [0.29, 1.81], P<0.01) and HbA1c (MD=0.23, 95% CI [0.02, 0.45], P=0.008). There were also improvements in treatment response rates (OR=3.41, 95% CI [2.38, 4.90], P<0.01) and control rates (OR=2.47, 95% CI [1.91, 3.20], P<0.01). CONCLUSION: Adding LDP to Western medicine might improve treatment outcomes of diabetes, including FBG, 2hPG, response rates and control rates. |
| File Format | HTM / HTML |
| ISSN | 16720415 |
| Issue Number | 10 |
| Volume Number | 19 |
| e-ISSN | 19930402 |
| Journal | Chinese Journal of Integrative Medicine |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2013-10-01 |
| Publisher Place | China |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Therapeutics Diabetes Mellitus, Type 2 Drug Therapy Drugs, Chinese Herbal Therapeutic Use Hypoglycemic Agents Randomized Controlled Trials As Topic Blood Glucose Metabolism Case-control Studies Blood Adverse Effects Fasting Gliclazide Hemoglobin A, Glycosylated Humans Metformin Publication Bias Treatment Outcome Western World Journal Article Meta-analysis Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Complementary and Alternative Medicine |
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