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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhu, Xiao-xin Li, Yu-jie Yang, Lan Zhang, Dong Chen, Ying Kmonickova, Eva Weng, Xiao-gang Yang, Qing Zídek, Zdenek |
| Description | Country affiliation: China Author Affiliation: Zhu XX ( Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.) |
| Abstract | OBJECTIVE: To study possible immunobiological potential of Osmunda japonica Thunb. METHODS: Immunomodulatory effects of ethanol extracts prepared from rhizomes of O. japonica and phenolic compounds isolated from the extracts were investigated under the in vitro conditions using the rat peritoneal cells (2×10(6)/mL; 24 h culture). Biosynthesis of nitric oxide (NO) was assayed by Griess reagent, production of prostaglandin E2 (PGE2) and secretion of cytokines were determined by enzyme-linked immunoabsorbent assay. RESULTS: The extracts activated dose dependently, with the onset at 2.5-5 µmol/L concentrations, the high output NO production, and secretion of interferon-γ (IFN-γ), tumor necrosis factor- (TNF- ) and interleukin-1ß (IL-1ß). Mild enhancement of NO was produced by the aldehyde-type phenolics 4-hydroxybenzaldehyde and 3,4-hydroxybenzaldehyde. In contrasts, the acetone-type phenolics 4-hydroxybenzalacetone and 3,4-hydroxybenzalacetone inhibited production of immune mediators including cytokines (TNF- , IL-1ß, IL-6), NO, and PGE2. The 3,4-hydroxybenzalacetone was more effective than 4-hydroxybenzaldehyde. The IC50s estimates ranged within the interval of 5-10 µmol/L. No signs of cytotoxicity were observed up to the 50 µmol/L concentration of the compounds. CONCLUSION: Phenolic compounds contained in medicinal herb Osmunda japonica possess distinct immunomodulatory activity. |
| File Format | HTM / HTML |
| ISSN | 16720415 |
| Issue Number | 10 |
| Volume Number | 19 |
| e-ISSN | 19930402 |
| Journal | Chinese Journal of Integrative Medicine |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2013-10-01 |
| Publisher Place | China |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Therapeutics Ferns Chemistry Immunologic Factors Pharmacology Phenols Plant Extracts Animals Cell Survival Drug Effects Cells, Cultured Dinoprostone Biosynthesis Female Interferon-gamma Lipopolysaccharides Nitric Oxide Nitric Oxide Synthase Type Ii Genetics Metabolism Peritoneum Cytology Isolation & Purification Polymyxin B Proline Analogs & Derivatives Rna, Messenger Rats Rats, Wistar Thiocarbamates Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Complementary and Alternative Medicine |
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