NDLI: Aqueous extracts of Ocimum grasstimum inhibits lipopolysaccharide-induced interleukin-6 and interleukin-8 expression in airway epithelial cell BEAS-2B.

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Aqueous extracts of Ocimum grasstimum inhibits lipopolysaccharide-induced interleukin-6 and interleukin-8 expression in airway epithelial cell BEAS-2B.

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Aqueous extracts of Ocimum grasstimum inhibits lipopolysaccharide-induced interleukin-6 and interleukin-8 expression in airway epithelial cell BEAS-2B.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jiao, Ze-long Li, Lei Zhao, Zi-gang Liu, Dan Lin, Bi-wen Li, Heng-jin
Description	Country affiliation: China Author Affiliation: Jiao ZL ( Department of Dermatology, The Chinese People's Liberation Army General Hospital, Beijing, 100853, China.)
Abstract	OBJECTIVE: To investigate the antiinflammatory activities of aqueous extract of Occimum gratissmium (OGE) with emphasis on expression of proinflammatory cytokines in Lipopolysaccharide (LPS)-stimulated epithelial cell BEAS-2B. METHODS: Effects of OGE on cell viability were determined by MTT assay. mRNA expression were analyzed by and reverse transcription polymerase chain reaction (RT-PCR) and quantitative real-time PCR. Activation of kinase cascades was investigated by immunoblot. Intracellular reactive oxygen species (ROS) was analyzed by flow cytometry. RESULTS: OGE (<200 µg/mL) treatment or pretreatment and following LPS exposure slightly affected viability of BEAS-2B cells. Increase of interleukin (IL)-6 and IL-8 and the elevated level of intracellular ROS in LPS-stimulated BEAS-2B cells were diminished by OGE pretreatment in a dose-dependent manner. OGE suppressed inflammatory response-associated mitogen-activated protein kinases (MAPKs) and Akt activation. Additionally, OGE pretreatment increased level of cellular inhibitor of κB (IκB ) and inhibited nuclear translocation of nuclear factor kappa B (NF-κB). CONCLUSION: These findings indicate that significant suppression of IL-6 and IL-8 expressions in LPS-stimulated BEAS-2B cells by OGE may be attributed to inhibiting activation of MAPKs and Akt and consequently suppressing nuclear translocation of NF-κB.
File Format	HTM / HTML
ISSN	16720415
Issue Number	10
Volume Number	19
e-ISSN	19930402
Journal	Chinese Journal of Integrative Medicine
Language	English
Publisher	Springer
Publisher Date	2013-10-01
Publisher Place	China
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Therapeutics Epithelial Cells Metabolism Interleukin-6 Interleukin-8 Lipopolysaccharides Pharmacology Ocimum Chemistry Plant Extracts Respiratory System Cytology Cell Nucleus Drug Effects Cell Survival Cytosol Enzymology Gene Expression Regulation Humans I-kappa B Proteins Genetics Intracellular Space Mitogen-activated Protein Kinases Nf-kappa B Phosphorylation Protein Transport Proto-oncogene Proteins C-akt Rna, Messenger Reactive Oxygen Species Water Journal Article
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Complementary and Alternative Medicine

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Aqueous extracts of Ocimum grasstimum inhibits lipopolysaccharide-induced interleukin-6 and interleukin-8 expression in airway epithelial cell BEAS-2B.