NDLI: Association between exercise hemodynamics and changes in local vascular function following acute exercise.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gonzales, Joaquin U. Thompson, Benjamin C. Thistlethwaite, John R. Scheuermann, Barry W.
Description	Country affiliation: United States Author Affiliation: Gonzales JU ( Cardiopulmonary and Metabolism Research Laboratory, Department of Kinesiology, The University of Toledo, Toledo, OH 43606-3390, USA.)
Abstract	Skeletal muscle contractions are associated with physical stimuli that act upon muscle vasculature, including increased shear stress and blood pressure. It is unclear if acute dynamic exercise alters local vascular function. The purpose of this study was to examine the role of exercise hemodynamics on the effects of acute exercise on vascular function, as evaluated by brachial artery flow-mediated dilation (FMD). Healthy individuals (n = 14; age, 18-34 years) performed 30 min of handgrip exercise at fast and slow contractions. Blood pressure during exercise was measured using a Vasotrac system (Medwave Inc.), while shear rate during exercise and FMD at rest and after 30 min of recovery from exercise were measured in the brachial artery of the active arm using Doppler ultrasound. Estimated contractile work was correlated with blood pressure (r = 0.61, p < 0.01) and retrograde shear rate (r = -0.78, p < 0.01). As a result, blood pressure was higher (p < 0.05) and oscillatory shear index was lower (p < 0.05) during slow as compared with fast contractions. On average, FMD was unchanged following fast contractions (5.4 ± 3.4%dilation to 6.1 ± 3.8%dilation; p = 0.19), but significantly reduced following slow contractions (6.9 ± 4.2%dilation to 3.6 ± 2.5%dilation; p = 0.01). Within slow contractions, subgroup analysis revealed blood pressure to associate with the change in FMD; such that individuals with mean blood pressure >100 mm Hg (range, 102-139 mm Hg) during exercise had larger decreases in FMD than individuals with lower exercise blood pressure. These results indicate that impaired local vascular function following acute exercise with high contractile activity is associated with blood pressure stimuli in healthy individuals.
File Format	HTM / HTML
ISSN	17155312
Issue Number	1
Volume Number	36
e-ISSN	17155320
Journal	Applied Physiology, Nutrition, and Metabolism
Language	English
Publisher	Canadian Science Publishing
Publisher Date	2011-02-01
Publisher Place	Canada
Access Restriction	Subscribed
Subject Keyword	Discipline Physiology Discipline Metabolism Discipline Nutritional Sciences Discipline Sports Medicine Blood Flow Velocity Blood Pressure Muscle Contraction Physical Exertion Adult Brachial Artery Physiology Endothelium, Vascular Female Hand Strength Humans Male Rest Stress, Mechanical Vasodilation Young Adult Journal Article Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Physiology Endocrinology, Diabetes and Metabolism Physiology (medical) Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in