NDLI: Adiposity and aerobic fitness are associated with metabolic disease risk in children.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Parrett, Anne L. Valentine, Rudy J. Arngrímsson, Sigurbjörn A. Castelli, Darla M. Evans, Ellen M.
Description	Country affiliation: United States Author Affiliation: Parrett AL ( University of Illinois at Urbana-Champaign, Department of Kinesiology and Community Health, MC-052, Urbana, IL 61801, USA.)
Abstract	To examine the relative association of physical activity, cardiorespiratroy fitness (CRF), and adiposity with risk for metabolic disease in prepubescent children. Forty-six prepubescent children (age, 9.4 ± 1.7 years; 24 males) were assessed for adiposity (%fat) via dual-energy X-ray absorptiometry, CRF with a peak graded exercise test, and physical activity using pedometers. Metabolic disease risk was assessed by a composite score of the following factors: waist circumference (WC), mean arterial pressure (MAP), triacylglycerol (TAG), total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C ratio), glucose, and insulin. Adiposity was correlated with metabolic disease risk score, as well as homeostasis model assessment of insulin resistance (HOMA-IR), TAG, TC/HDL-C ratio, WC, insulin, and MAP (r range = 0.33 to 0.95, all p < 0.05). Physical activity was negatively associated with metabolic disease risk score, as well as HOMA-IR, TAG, WC, insulin, and MAP (r range = -0.32 to -0.49, all p < 0.05). CRF was inversely associated with metabolic disease risk score and HOMA-IR, TAG, TC/HDL-C ratio, WC, insulin, and MAP (r range = -0.32 to -0.63, all p < 0.05). Compared across fitness-physical activity and fatness groups, the low-fit-high-fat and the low-activity-high-fat groups had higher metabolic risk scores than both low-fat groups. Regression analyses revealed sexual maturity (ß = 0.27, p = 0.044) and %fat (ß = 0.49, p = 0.005) were the only independent predictors of metabolic disease risk score, explaining 4.7% and 9.5% of the variance, respectively. Adiposity appears to be an influential factor for metabolic disease risk in prepubescent children, and fitness is protective against metabolic disease risk in the presence of high levels of adiposity.
File Format	HTM / HTML
ISSN	17155312
Issue Number	1
Volume Number	36
e-ISSN	17155320
Journal	Applied Physiology, Nutrition, and Metabolism
Language	English
Publisher	Canadian Science Publishing
Publisher Date	2011-02-01
Publisher Place	Canada
Access Restriction	Subscribed
Subject Keyword	Discipline Physiology Discipline Metabolism Discipline Nutritional Sciences Discipline Sports Medicine Adiposity Body Composition Metabolic Syndrome X Complications Motor Activity Obesity Physical Fitness Absorptiometry, Photon Methods Analysis Of Variance Blood Glucose Metabolism Child Cholesterol, Hdl Blood Female Humans Insulin Insulin Resistance Linear Models Male Oxygen Consumption Risk Factors Triglycerides Waist Circumference Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Physiology Endocrinology, Diabetes and Metabolism Physiology (medical) Sports Science

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