NDLI: HLA-class II alleles in patients with drug-resistant pulmonary tuberculosis in Kazakhstan.

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HLA-class II alleles in patients with drug-resistant pulmonary tuberculosis in Kazakhstan.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kuranov, A. B. Kozhamkulov, U. A. Vavilov, M. N. Belova, E. S. Bismilda, V. L. Alenova, A. H. Ismailov, S. S. Momynaliev, K. T.
Spatial Coverage	Kazakhstan
Description	Country affiliation: Kazakhstan Author Affiliation: Kuranov AB ( National Center for Biotechnology, Astana, Kazakhstan.)
Abstract	The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Some studies have reported that HLA class II genes play a strong role in severe cases of pulmonary tuberculosis (PTB) in several populations. Thus the aim of the study was to compare the HLA-class II alleles of patients with drug resistant tuberculosis with those of healthy controls from the same ethnic group in Kazakhstan. The aim of the present study was to evaluate the correlation of HLA-class II alleles by patients with drug resistant tuberculosis and the healthy controls of the same ethnic group in Kazakhstan. The HLA-class II alleles of 76 patients with tuberculosis (TB) and 157 healthy volunteers were investigated using sequence-based typing (SBT)-method. HLA-DQA103:02 HLA-DRB108:01 and DRB1*08:03 occurred more frequently (P = 0.05) in patients with drug resistant tuberculosis than in controls. We observed a possible association between certain HLA alleles and TB that are specific for the Kazakh population. Further studies are needed to confirm our findings using a larger number of patients with drug resistant tuberculosis.
File Format	HTM / HTML
ISSN	20592302
Issue Number	2
Volume Number	83
e-ISSN	20592310
Journal	Tissue Antigens
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2014-02-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Immunology Genetic Predisposition To Disease Hla-dq Alpha-chains Genetics Hla-drb1 Chains Haplotypes Tuberculosis, Multidrug-resistant Tuberculosis, Pulmonary Adult Antitubercular Agents Therapeutic Use Case-control Studies Female Gene Frequency Classification Immunology Histocompatibility Testing Humans Kazakhstan Male Middle Aged Mycobacterium Tuberculosis Drug Effects Drug Therapy Microbiology Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology and Allergy Immunology

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HLA-class II alleles in patients with drug-resistant pulmonary tuberculosis in Kazakhstan.

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