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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rong, Y-H Wan, Z-H Song, H. Li, Y-L Zhu, B. Zang, H. Zhao, Y. Liu, H-L Zhang, A-M Xiao, L. Xin, S-J You, S-L |
| Description | Country affiliation: China Author Affiliation: Rong YH ( Medical School of Chinese PLA, Beijing, China) |
| Abstract | Hepatitis B virus (HBV) infection is one of the major causes of chronic liver inflammation. Tim-3 acts as a negative regulatory molecule and plays a critical role in immune tolerance. In the current study, we investigated Tim-3 expression on peripheral monocytes and CD3+CD16/CD56+ natural killer like T (NKT-like) cells in chronic hepatitis B (CHB) patients. Peripheral blood mononuclear cells (PBMCs) were isolated from 52 CHB patients and 60 healthy controls. Tim-3+CD14+ cells and Tim-3+CD3+CD16/CD56+ cells were analyzed by flow cytometry. Results showed that expression of Tim-3 was significantly increased on both the monocytes and NKT-like cells in CHB patients than in controls (P = 0.002 and P < 0.001, respectively). Tim-3 levels on monocytes and NKT-like cells were further upregulated in patients with acute-on-chronic liver failure (ACLF). In addition, we assessed the correlation of Tim-3 expression with levels of alanine aminotransferase (ALT) and tumor necrosis factor alpha (TNF- ). Data revealed that Tim-3 expression on both monocytes and NKT-like cells was positively correlated with level of ALT (r = 0.59, P < 0.001, and r = 0.60, P < 0.001, respectively), whereas Tim-3 expression on NKT-like cells was negatively correlated with serum level of TNF- (r = -0.54, P < 0.001) in CHB patients. Our results suggest that Tim-3 may play important roles in the pathogenesis of CHB. |
| File Format | HTM / HTML |
| ISSN | 20592302 |
| Issue Number | 2 |
| Volume Number | 83 |
| e-ISSN | 20592310 |
| Journal | Tissue Antigens |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2014-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Genetics Discipline Immunology End Stage Liver Disease Genetics Gene Expression Hepatitis B, Chronic Killer Cells, Natural Metabolism Liver Failure, Acute Membrane Proteins Monocytes Adult Alanine Transaminase Immunology Antigens, Cd3 Antigens, Cd56 Case-control Studies Etiology Virology Female Gpi-linked Proteins Hepatitis B Virus Complications Humans Immune Tolerance Male Receptors, Igg Signal Transduction Tumor Necrosis Factor-alpha Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Immunology and Allergy Immunology |
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