NDLI: Analysis of high-resolution HLA-A, -B, -Cw, -DRB1, and -DQB1 alleles and haplotypes in 718 Chinese marrow donors based on donor-recipient confirmatory typings.

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Analysis of high-resolution HLA-A, -B, -Cw, -DRB1, and -DQB1 alleles and haplotypes in 718 Chinese marrow donors based on donor-recipient confirmatory typings.

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Analysis of high-resolution HLA-A, -B, -Cw, -DRB1, and -DQB1 alleles and haplotypes in 718 Chinese marrow donors based on donor-recipient confirmatory typings.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hei, A-L Li, W. Deng, Z-H He, J. Jin, W-M Du, D. Zhou, X-Y Xiao, Y. Zhang, Z-X Cai, J-P
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Hei AL ( The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics & Beijing Hospital, Ministry of Health, Beijing 100730, China.)
Abstract	High-resolution human leucocyte antigen (HLA)-A, -B, -Cw, -DRB1, and -DQB1 alleles and haplotype frequencies were analysed from 718 Chinese healthy donors selected from the Chinese Marrow Donor Program registry based on HLA donor-recipient confirmatory typings. A total of 28 HLA-A, 61 HLA-B, 30 HLA-Cw, 40 HLA-DRB1 and 18 HLA-DQB1 alleles were identified, and HLA-A1101, A2402, A0201, B4001, Cw0702, Cw0102, Cw0304, DRB10901, DRB11501, DQB10301, DQB10303 and DQB10601 were found with frequencies higher than 10% in this study population. Multiple-locus haplotype analysis by the maximum-likelihood method revealed 45 A-B, 38 Cw-B, 47 B-DRB1, 29 DRB1-DQB1, 24 A-B-DRB1, 38 A-Cw-B, 23 A-Cw-B-DRB1, 33 Cw-B-DRB1-DQB1 and 22 A-Cw-B-DRB1-DQB1 haplotypes with frequencies >0.5%. The most common two-, three-, four- and five-locus haplotypes in this population were: A0207-B4601 (7.34%), Cw0102-B4601 (8.71%), B1302-DRB10701 (6.19%), DRB10901-DQB10303 (14.27%), A3001-B1302-DRB10701 (5.36%), A0207-Cw0102-B4601 (7.06%), A3001-Cw0602-B1302-DRB10701 (5.36%), Cw0602-B1302-DRB10701-DQB10202 (6.12%) and A3001-Cw0602-B1302-DRB10701-DQB1*0202 (5.29%). Presentation of the high-resolution alleles and haplotypes data at HLA-A, -B, -Cw, -DRB1 and -DQB1 loci will be useful for HLA matching in transplantation as well as for other medical and anthropological applications in the Chinese population.
File Format	HTM / HTML
ISSN	17443121
Issue Number	5
Volume Number	36
e-ISSN	1744313X
Journal	International Journal of Immunogenetics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2009-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Immunology Alleles Bone Marrow Haplotypes Histocompatibility Antigens Genetics Histocompatibility Testing Methods Tissue Donors China Gene Frequency Hla-a Antigens Hla-b Antigens Hla-c Antigens Hla-dq Antigens Hla-dq Beta-chains Hla-dr Antigens Hla-drb1 Chains Humans Registries Reproducibility Of Results Transplantation Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Immunology Genetics (clinical)

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