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Anti-oxidant properties of high-density lipoprotein and atherosclerosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Podrez, Eugene A.
Description	Country affiliation: United States Author Affiliation: Podrez EA ( Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. podreze@ccf.org)
Abstract	1. High-density lipoprotein (HDL) is one of the major carriers of cholesterol in the blood. It attracts particular attention because, in contrast with other lipoproteins, many physiological functions of HDL influence the cardiovascular system in favourable ways unless HDL is modified pathologically. 2. The best known function of HDL is the capacity to promote cellular cholesterol efflux from peripheral cells and deliver cholesterol to the liver for excretion, thereby playing a key role in reverse cholesterol transport. The functions of HDL that have recently attracted attention include anti-inflammatory and anti-oxidant activities. High anti-oxidant and anti-inflammatory activities of HDL are associated with protection from cardiovascular disease. 3. Atheroprotective activities, as well as a functional deficiency of HDL, ultimately depend on the protein and lipid composition of HDL. Conversely, these activities are compromised in many pathological states associated with inflammation. 4. The focus of the present review is on the anti-oxidant and anti-inflammatory functions of HDL and its individual components in relation to protection from atherosclerosis.
File Format	HTM / HTML
ISSN	03051870
e-ISSN	14401681
DOI	10.1111/j.1440-1681.2010.05380.x
Journal	Clinical and Experimental Pharmacology and Physiology
Issue Number	7
Volume Number	37
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-07-01
Publisher Place	Australia
Access Restriction	Open
Subject Keyword	Discipline Physiology Discipline Pharmacology Antioxidants Physiology Atherosclerosis Metabolism Cholesterol Lipoproteins, Hdl 1-alkyl-2-acetylglycerophosphocholine Esterase Animals Anti-inflammatory Agents Pharmacology Chemistry Aryldialkylphosphatase Prevention & Control Esterases Glutathione Peroxidase Mice Oxidative Stress Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Pharmacology

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