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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tselepis, Alexandros D. Hahalis, George Tellis, Constantinos C. Papavasiliou, Eleni C. Mylona, Panagiota T. Kourakli, Alexandra Alexopoulos, Dimitrios C. |
| Description | Country affiliation: Greece Author Affiliation: Tselepis AD ( Department of Chemistry, University of Ioannina, Ioannina, Greece. atselep@uoi.gr) |
| Abstract | Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an independent cardiovascular risk factor. We investigated the plasma levels of Lp-PLA(2) activity and mass as a function of plasma lipid levels, LDL subclass profile, and oxidative stress in patients with ß-thalassemia. Thirty-five patients with ß-thalassemia major (ß-TM) and 25 patients with ß-thalassemia intermedia (ß-TI) participated in the study. Lp-PLA(2) activity and mass were measured in total plasma, in apolipoprotein (apo)B-depleted plasma (HDL-Lp-PLA(2)), and in LDL subclasses. Lp-PLA(2) activity produced and secreted from peripheral blood monocytes in culture was also determined. Patients with ß-thalassemia are characterized by a predominance of small-dense LDL particles, increased oxidative stress, and very high plasma levels of Lp-PLA(2) mass and activity, despite low LDL-cholesterol levels. A significant positive correlation between plasma Lp-PLA(2) activity or mass and 8-isoprostane (8-epiPGF2a) and ferritin levels as well as intima-media thickness (IMT) values was observed. An increase in secreted and cell-associated Lp-PLA(2) activity from monocytes in culture was observed in both patient groups. The HDL-Lp-PLA(2) activity and mass as well as the ratio of HDL-Lp-PLA(2)/plasma Lp-PLA(2) were significantly higher in both patient groups compared with the control group. In conclusion, patients with ß-thalassemia exhibit high plasma Lp-PLA(2) levels, attributed to increased enzyme secretion from monocytes/macrophages and to the predominance of sdLDL particles in plasma. Plasma Lp-PLA(2) is correlated with carotid IMT, suggesting that this enzyme may be implicated in premature carotid atherosclerosis observed in ß-thalassemia. |
| File Format | HTM / HTML |
| ISSN | 00222275 |
| e-ISSN | 15397262 |
| DOI | 10.1194/jlr.M007229 |
| Journal | The Journal of Lipid Research |
| Issue Number | 11 |
| Volume Number | 51 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology |
| Publisher Date | 2010-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Biochemistry 1-alkyl-2-acetylglycerophosphocholine Esterase Blood Metabolism Beta-thalassemia Enzymology Secretion Apolipoproteins B Aryldialkylphosphatase Blood Platelets Cell Adhesion Dinoprost Analogs & Derivatives Lipoproteins, Ldl Monocytes Pathology Oxidative Stress |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Endocrinology |
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