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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lawson, Heather A. Zelle, Kathleen M. Fawcett, Gloria L. Wang, Bing Pletscher, L. Susan Maxwell, Taylor J. Ehrich, Thomas H. Kenney-Hunt, Jane P. Wolf, Jason B. Semenkovich, Clay F. Cheverud, James M. |
| Description | Country affiliation: United States Author Affiliation: Lawson HA ( Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO, USA. lawsonh@pcg.wustl.edu) |
| Abstract | Variation in serum cholesterol, free-fatty acids, and triglycerides is associated with cardiovascular disease (CVD) risk factors. There is great interest in characterizing the underlying genetic architecture of these risk factors, because they vary greatly within and among human populations and between the sexes. We present results of a genome-wide scan for quantitative trait loci (QTL) affecting serum cholesterol, free-fatty acids, and triglycerides in an F(16) advanced intercross line of LG/J and SM/J (Wustl:LG,SM-G16). Half of the population was fed a high-fat diet and half was fed a relatively low-fat diet. Context-dependent genetic (additive and dominance) and epigenetic (imprinting) effects were characterized by partitioning animals into sex, diet, and sex-by-diet cohorts. Here we examine genetic, environmental, and genetic-by-environmental interactions of QTL overlapping previously identified loci associated with CVD risk factors, and we add to the serum lipid QTL landscape by identifying new loci. |
| File Format | HTM / HTML |
| ISSN | 00222275 |
| e-ISSN | 15397262 |
| DOI | 10.1194/jlr.M006957 |
| Journal | The Journal of Lipid Research |
| Issue Number | 10 |
| Volume Number | 51 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology |
| Publisher Date | 2010-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Biochemistry Diet Epigenesis, Genetic Genetics Genetic Variation Lipids Blood Animals Cardiovascular Diseases Crosses, Genetic Mice Models, Animal Quantitative Trait Loci Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Endocrinology |
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