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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kobal, Silvestra Cebulj-Kadunc, Nina Cestnik, Vojteh |
| Description | Country affiliation: Slovenia Author Affiliation: Kobal S ( Institute of Physiology, Pharmacology and Toxicology, Veterinary Faculty, Gerbiceva 60, 1000 Ljubljana, Slovenia, Slovenia.); Cebulj-Kadunc N ( Institute of Physiology, Pharmacology and Toxicology, Veterinary Faculty, Gerbiceva 60, 1000 Ljubljana, Slovenia, Slovenia.); Cestnik V ( Institute of Physiology, Pharmacology and Toxicology, Veterinary Faculty, Gerbiceva 60, 1000 Ljubljana, Slovenia, Slovenia.) |
| Abstract | The influence of sublethal doses of 2,4-dichlorophenoxyacetic acid (2,4-D) on serum T3 and T4 concentrations in Hsd Cpb: Wistar rats of both sexes was studied. The trial was performed on 24 males and females respectively, each divided into three groups of 8 animals (control, groups 1 and 2). Aqueous solution of the compound (11 mg/kg body weight - group 1 and 110 mg/kg body weight - group 2) or clean tap water (control group) was used. Aliquots of 2.4 ml/kg body weight were administered with a stomach tube from the 1 to 10 day of the experiment. Three days before the first treatment and on the 6 and 13 day of the experiment the serum T3 and T4 concentrations were determined by commercial radioimmunoassay kits (Byk-Sangtec Diagnostica), validated for rats. A significant decrease of serum T4 (P < 0.01) and T3 (P < 0.001) was determined in males of groups 1 and 2 during the experiment. On the 6 day of experiment serum T4 and T3 values were significantly lower (P < 0.001 and 0.01 respectively) in group 2 than in the controls and group 1 of both males and females. During the whole experiment serum T4 levels were lower in females than in males (P < 0.05). |
| File Format | HTM / HTML |
| ISSN | 00316768 |
| Issue Number | Suppl 1 |
| Journal | Pflügers Archiv - European Journal of Physiology |
| Volume Number | 440 |
| e-ISSN | 14322013 |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2000-01-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Physiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Clinical Biochemistry |
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