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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hudler, Petra Gubina, Marija Hren, Natasa Ihan Seme, Katja Malovrh, Tadej Gale, Nina Ihan, Alojz |
| Description | Country affiliation: Slovenia Author Affiliation: Hudler P ( Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia, Slovenia.); Gubina M ( Institute for Microbiology and Immunology, Medical Faculty Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia, Slovenia.); Hren NI ( Department of Maxilofacial and Oral Surgery, University Clinical Centre Ljubljana, Zaloska 7, 1000 Ljubljana, Slovenia, Slovenia.); Seme K ( Institute for Microbiology and Immunology, Medical Faculty Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia, Slovenia.); Malovrh T ( Institute for Microbiology and Immunology, Medical Faculty Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia, Slovenia.); Gale N ( Institute of Pathology, Medical Faculty, Zaloska 7, 1000 Ljubljana, Slovenia, Slovenia.); Ihan A ( Institute of Microbiology and Immunology, Medical Faculty, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia, Slovenia.) |
| Abstract | We established a mouse model of chronic bacterial infection (cotton trap) to get a deeper insight into interactions between immune cells and bacterial strains, that are most commonly isolated from periapical processes. We have used flow cytometry to identify the presence of intracellular cytokines of activated T cells collected from cotton traps, previously infected with different strains of bacteria and implanted subcutaneously into the back of the mice. We provide an evidence that anaerobic bacteria (Bacteroides sp.) and nocardiae are more effective in inducing cytotoxic immunity and Th1 response compared to oral streptococci. Differences in immune response against anaerobic bacteria when compared to streptococci are probably dependent on some non-specific immune cell stimulation (e.g. by bacterial cell wall components), nevertheless the role of specific antigen-dependent immune mechanism can not be excluded. |
| File Format | HTM / HTML |
| ISSN | 00316768 |
| Issue Number | Suppl 1 |
| Journal | Pflügers Archiv - European Journal of Physiology |
| Volume Number | 440 |
| e-ISSN | 14322013 |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2000-01-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Physiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Clinical Biochemistry |
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