NDLI: Activation of big conductance $Ca^{2+}-activated$ $K^{+}$ channels (BK) protects the heart against ischemia

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Activation of big conductance $Ca^{2+}-activated$ $K^{+}$ channels (BK) protects the heart against ischemia–reperfusion injury

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bentzen, Bo Hjorth Osadchii, Oleg Jespersen, Thomas Hansen, Rie Schultz Olesen, Søren-Peter Grunnet, Morten
Description	Country affiliation: Denmark Author Affiliation: Bentzen BH ( Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Denmark. mgrunnet@mfi.ku.dk)
Abstract	Activation of the large-conductance $Ca^{2+}-activated$ $K^{+}$ channel (BK) in the cardiac inner mitochondrial membrane has been suggested to protect the heart against ischemic injury. However, these findings are limited by the low selectivity profile and potency of the BK channel activator (NS1619) used. In the present study, we address the cardioprotective role of BK channels using a novel, potent, selective, and chemically unrelated BK channel activator, NS11021. Using electrophysiological recordings of heterologously expressed channels, NS11021 was found to activate BK α + β1 channel complexes, while producing no effect on cardiac $K_{ATP}$ channels. The cardioprotective effects of NS11021-induced BK channel activation were studied in isolated, perfused rat hearts subjected to 35 min of global ischemia followed by 120 min of reperfusion. 3 μM NS11021 applied prior to ischemia or at the onset of reperfusion significantly reduced the infarct size [control: 44.6 ± 2.0%; NS11021: 11.4 ± 2.0%; NS11021 at reperfusion: 19.8 ± 3.3% (p < 0.001 for both treatments compared to control)] and promoted recovery of myocardial performance. Co-administration of the BK-channel inhibitor paxilline (3 μM) antagonized the protective effect. These findings suggest that tissue damage induced by ischemia and reperfusion can be reduced by activation of cardiac BK channels.
File Format	HTM / HTML
ISSN	00316768
Issue Number	5
Volume Number	457
e-ISSN	14322013
Journal	Pflügers Archiv - European Journal of Physiology
Language	English
Publisher	Springer
Publisher Date	2009-03-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Physiology Large-conductance Calcium-activated Potassium Channels Physiology Myocardial Reperfusion Injury Prevention & Control Atp-binding Cassette Transporters Biosynthesis Drug Effects Animals Cells, Cultured Humans In Vitro Techniques Indoles Pharmacology Katp Channels Male Mitochondria, Heart Myocardial Contraction Oocytes Metabolism Potassium Channels, Inwardly Rectifying Rats Receptors, Drug Sulfonylurea Receptors Tetrazoles Thiourea Analogs & Derivatives Ventricular Function Xenopus Laevis Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

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