NDLI: Expression and function of $K_{v}7$ channels in murine myometrium throughout oestrous cycle

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Expression and function of $K_{v}7$ channels in murine myometrium throughout oestrous cycle

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	McCallum, Laura A. Greenwood, Iain A. Tribe, Rachel M.
Description	Country affiliation: United kingdom Author Affiliation: McCallum LA ( King's College London, St Thomas' Hospital Campus, UK. laura.mccallum@kcl.ac.uk)
Abstract	This study represents an extensive characterisation of the expression and functional impact of KCNQ and KCNE accessory subunits in a murine uterus using a combination of quantitative reverse transcription polymerase chain reaction, Western blot analysis, patch clamp electrophysiology and isometric tension recording. The use of uterine tissue throughout the oestrous cycle provided a physiological model with which to assess hormonal regulation of these genes. Messenger ribonucleic acid for all KCNQ genes were detected throughout the oestrous cycle with the KCNQ1 message predominant. KCNE isoforms were detected at each stage of the cycle. KCNE4 was the most abundant (p < 0.0001), and KCNQ1, KCNQ5 and KCNE1 were up-regulated in metestrous (p < 0.0001). The $K_{v}7$ channel inhibitor XE991 reduced outward $K^{+}$ currents and significantly increased spontaneous myometrial contractions (p < 0.05), whereas retigabine $(K_{v}7$ activator) significantly relaxed uterine tissues (p < 0.001). These data are the first to characterise KCNQ and KCNE gene expression in a cell type outside of neurons and the cardiovascular system.
File Format	HTM / HTML
ISSN	00316768
Issue Number	5
Volume Number	457
e-ISSN	14322013
Journal	Pflügers Archiv - European Journal of Physiology
Language	English
Publisher	Springer
Publisher Date	2009-03-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Physiology Estrous Cycle Physiology Kcnq1 Potassium Channel Myometrium Potassium Channels, Voltage-gated Animals Anthracenes Pharmacology Carbamates Chromans Female Biosynthesis Drug Effects Mice Mice, Inbred C57bl Phenylenediamines Potassium Channel Blockers Sulfonamides Uterine Contraction Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

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Expression and function of $K_{v}7$ channels in murine myometrium throughout oestrous cycle

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Expression and function of $K_{v}7$ channels in murine myometrium throughout oestrous cycle