NDLI: The Plasmodium falciparum-induced anion channel of human erythrocytes is an ATP-release pathway.

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The Plasmodium falciparum-induced anion channel of human erythrocytes is an ATP-release pathway.

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The Plasmodium falciparum-induced anion channel of human erythrocytes is an ATP-release pathway.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Akkaya, Canan Shumilina, Ekaterina Bobballa, Diwakar Brand, Verena B. Mahmud, Hasan Lang, Florian Huber, Stephan M.
Description	Country affiliation: Germany Author Affiliation: Akkaya C ( Department of Physiology, University of Tübingen, Germany.)
Abstract	Infection with the malaria parasite Plasmodium falciparum induces osmolyte and anion channels in the host erythrocyte membrane involving ATP release and autocrine purinergic signaling. P. falciparum-parasitized but not unstimulated uninfected erythrocytes released ATP in a 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB; 7 microM)-sensitive and serum album (SA; 0.5% w/v)-stimulated manner. Since Plasmodium infection of human erythrocytes induces SA-dependent outwardly (OR) and SA-independent inwardly rectifying (IR) anion conductances, we tested whether the infection-induced OR channels directly generate an ATP release pathway. P. falciparum-parasitized erythrocytes were recorded in whole-cell mode with either Cl(-) or ATP as the only anion in the bath or pipette. In parasitized cells with predominant OR activity, replacement of bath NaCl by Na-ATP (NMDG-Cl pipette solution) shifted the current reversal potential (V (rev)) from -2 +/- 1 to +51 +/- 3 mV (n = 15). In cells with predominant IR activity, in contrast, the same maneuver induced a shift of V (rev) to significantly larger (p < or = 0.05, two-tailed t test) values (from -3 +/- 1 to +66 +/- 8 mV; n = 5) and an almost complete inhibition of outward current. The anion channel blocker NPPB reversibly decreased the ATP-generated OR currents from 1.1 +/- 0.1 nS to 0.2 +/- 0.05 nS and further shifted V (rev) to +87 +/- 7 mV (n = 12). The NPPB-sensitive fraction of the OR reversed at +48 +/- 4 mV suggesting a relative permeability of P (ATP)/P (Cl) approximately 0.01. Together, these data raise the possibility that the OR might be the electrophysiological correlate of an erythrocyte ATP release pathway.
File Format	HTM / HTML
ISSN	00316768
Issue Number	5
Volume Number	457
e-ISSN	14322013
Journal	Pflügers Archiv - European Journal of Physiology
Language	English
Publisher	Springer
Publisher Date	2009-03-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Physiology Adenosine Triphosphate Metabolism Erythrocytes Ion Channels Physiology Plasmodium Falciparum Animals Anions Erythrocyte Membrane Drug Effects Parasitology Humans Nitrobenzoates Pharmacology Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

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