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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sayed, Suhail I. Dwivedi, Raghav C. Katna, Rakesh Garg, Anubha Pathak, K. A. Nutting, Christopher M. Rhys-Evans, Peter Harrington, Kevin J. Kazi, Rehan |
| Description | Country affiliation: India Author Affiliation: Sayed SI ( ENT Dept., Grant Medical College, B.R. Ambedkar Road, Byculla, Mumbai 8, India. drsuhailsayed@gmail.com) |
| Abstract | Head and neck squamous cell cancer (HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of this disease. Efforts are ongoing throughout the world to improve early detection and prevention of HNSCCs. Often, treatment fails to obtain total cancer cure and this is more likely with advanced stage disease. In recent years it appears that one of the key determinants of treatment failure may be the presence of cancer stem cells (CSC) that 'escape' currently available therapies. CSCs form a minute portion of the total tumour burden but may play a disproportionately important role in determining outcomes. Molecular mechanisms which underlie the genesis of CSCs are yet not fully understood and their detection within the total tumour bulk remains a challenge. Specific markers like Aldehyde dehydrogenase 1 (ALDH1), CD44 and Bmi-1 have shown early promising results both in CSC detection and in guiding treatment protocols. CSCs have been shown to be relatively resistant to standard treatment modalities. It is hoped that developing robust in vitro and in vivo experimental models of CSCs might provide a means of devising more effective therapeutic strategies. |
| File Format | HTM / HTML |
| ISSN | 13688375 |
| Issue Number | 4 |
| Volume Number | 47 |
| e-ISSN | 18790593 |
| Journal | Oral Oncology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Oncology Antigens, Cd44 Metabolism Cell Transformation, Neoplastic Pathology Neoplastic Stem Cells Carcinoma Therapy Carcinoma, Squamous Cell Early Detection Of Cancer Female Gene Expression Regulation, Neoplastic Head And Neck Neoplasms Humans Male Neoplasms, Squamous Cell Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oral Surgery Cancer Research Oncology |
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