NDLI: Cancer stem cells in head and neck squamous cell carcinoma: a review of current knowledge and future applications.

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Cancer stem cells in head and neck squamous cell carcinoma: a review of current knowledge and future applications.

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Observer variation in the histopathologic assessment of extranodal tumor spread in lymph node metastases in the neck.

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Comparing ERCC1 protein expression, mRNA levels, and genotype in squamous cell carcinomas of the head and neck treated with concurrent chemoradiation stratified by HPV status.

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Management of complete esophageal stricture after treatment of head and neck cancer using combined anterograde retrograde esophageal dilation.

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Cancer stem cells in head and neck squamous cell carcinoma: a review of current knowledge and future applications.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bhaijee, Feriyl Pepper, Dominique J. Pitman, Karen T. Bell, Diana
Description	Country affiliation: United States Author Affiliation: Bhaijee F ( Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA.)
Abstract	Head and neck squamous cell carcinoma (HNSCC) is a major cause of morbidity and mortality, and the alleviation thereof requires greater understanding of the pathobiologic behavior of HNSCC. Although the existence of cancer stem cells (CSCs) in most solid tumors has not been formally proven, application of the CSC concept has certainly enhanced understanding of HNSCC heterogeneity and progression. Recent data support the role of ALDH1(+) CD44(+) CSC in HNSCC, since the implantation of a few ALDH1(+) CD44(+) cells consistently gives rise to tumors that can be serially passaged in vivo. In addition to CSC biomarkers, recent explorations of CSC signaling pathways, gene expression, and localization in HNSCC carry significant clinical and therapeutic implications. Identification and characterization of CSC populations that regulate HNSCC growth, metastasis, and treatment resistance will facilitate development of novel diagnostic, therapeutic, and prognostic strategies. Furthermore, advances in multimodal imaging and nanotechnology, in conjunction with CSC models, may better elucidate the regulatory mechanisms that govern CSC biology in vivo, as well as develop platforms for targeted theragnostics. It is hoped that the promising applications of the CSC model in HNSCC will eventually alleviate the morbidity and mortality of this pervasive disease.
File Format	HTM / HTML
ISSN	10433074
Issue Number	6
Volume Number	34
e-ISSN	10970347
Journal	Head & Neck
Language	English
Publisher	Wiley
Publisher Date	2012-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Antigens, Cd44 Isoenzymes Humans Proto-oncogene Proteins Repressor Proteins Head And Neck Neoplasms Neoplastic Stem Cells Review Journal Article Nuclear Proteins Retinal Dehydrogenase Carcinoma, Squamous Cell Pathology Neoplasm Metastasis Polycomb Repressive Complex 1 Discipline General Surgery Cell Transformation, Neoplastic Genetics
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology

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