NDLI: Evaluation of MYB promoter methylation in salivary adenoid cystic carcinoma.

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Evaluation of MYB promoter methylation in salivary adenoid cystic carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shao, Chunbo Bai, Weiliang Junn, Jacqueline C. Uemura, Mamoru Hennessey, Patrick T. Zaboli, David Sidransky, David Califano, Joseph A. Ha, Patrick K.
Description	Country affiliation: United States Author Affiliation: Shao C ( Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA.)
Abstract	The transcription factor MYB was recently proposed to be a promising oncogene candidate in salivary gland adenoid cystic carcinoma (ACC). However, the up-regulation of MYB in ACC could not be explained solely by deletion of its 3' end. It is widely accepted that the promoter methylation status can regulate the transcription of genes, especially in human cancers. Therefore, it is important to know whether MYB promoter demethylation could explain the over-expression of MYB in ACC. By using the Methprimer program, we identified nine CpG islands in the promoter of MYB. All of these CpG islands were located within the -864 to +2082 nt region relative to the transcription start site of MYB. We then used bisulfite genomic sequencing to evaluate the methylation levels of the CpG islands of MYB in 18 primary ACC tumors, 13 normal salivary gland tissues and nine cancer cell lines. Using cell lines, we also determined the relative MYB expression levels and correlated these with the methylation levels. With bisulfite genomic sequencing, we found no detectable methylation in the CpG islands of MYB in either ACC or normal salivary gland tissues. There was a variable degree of MYB expression in the cell lines tested, but none of these cell lines demonstrated promoter methylation. Promoter hypomethylation does not appear to explain the differential expression of MYB in ACC. An alternative mechanism needs to be proposed for the transcriptional control of MYB in ACC.
File Format	HTM / HTML
ISSN	13688375
e-ISSN	18790593
DOI	10.1016/j.oraloncology.2011.01.008
Journal	Oral Oncology
Issue Number	4
Volume Number	47
Language	English
Publisher	Elsevier
Publisher Date	2011-04-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Oncology Carcinoma, Adenoid Cystic Metabolism Dna Methylation Salivary Gland Neoplasms Transcription Factors Genetics Pathology Cell Line, Tumor Cpg Islands Physiology Gene Expression Regulation, Neoplastic Promoter Regions, Genetic Up-regulation
Content Type	Text
Resource Type	Article
Subject	Oral Surgery Cancer Research Oncology

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Evaluation of MYB promoter methylation in salivary adenoid cystic carcinoma.

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