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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kiss, Orsolya Tokés, Anna-Mária Spisák, Sándor Szilágyi, Anna Lippai, Norbert Szász, A. Marcell Kulka, Janina |
| Description | Author Affiliation: Kiss O ( Semmelweis Egyetem, Általános Orvostudományi Kar, II. Patológiai Intézet, Budapest. kj@korb2.sote.hu) |
| Abstract | INTRODUCTION: Adenoid cystic carcinoma is a salivary gland-derived malignant tumor, but rarely it can originate from the breast, too. The salivary gland-derived form shows a very aggressive clinical outcome, while adenoid cystic carcinoma of the breast has mostly a very good prognosis. AIM: The aim of the authors was to compare the miRNA-expression profile of breast- and salivary gland-derived cases. METHOD: The miRNA-profiles of two salivary gland derived and two breast-derived adenoid cystic carcinoma tissues as well as one normal breast and one salivary gland tissues were analysed using the Affymetrix® Gene Chip. RESULTS: The expression of some miRNAs differed in the tumor tissues compared to their controls: the let-7b was overexpressed in salivary gland-derived adenoid cystic carcinoma, while decreased in breast-derived adenoid cystic carcinoma. In addition, the miR-24 was decreased in salivary gland-derived but overexpressed in breast-derived adenoid cystic carcinomas. The miR-181a-2* was only detected in salivary gland-derived adenoid cystic carcinomas. CONCLUSIONS: Through post-transcriptional regulation of the genes, the diverse expression of some miRNAs may partially explain the diverse clinical outcome of salivary gland-derived and breast-derived adenoid cystic carcinomas. |
| File Format | HTM / HTML |
| ISSN | 00306002 |
| e-ISSN | 17886120 |
| Journal | Orvosi Hetilap |
| Issue Number | 25 |
| Volume Number | 154 |
| Language | Hungarian |
| Publisher | Markusovszky Lajos |
| Publisher Date | 2013-06-23 |
| Publisher Place | Hungary |
| Access Restriction | Open |
| Subject Keyword | Micrornas Tumor Markers, Biological Gene Expression Regulation, Neoplastic Gene Expression Profiling Carcinoma, Adenoid Cystic Breast Neoplasms Down-regulation Up-regulation Genetics Discipline Medicine Salivary Gland Neoplasms |
| Alternative Title | MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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