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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kim, S. K. Shahid, S. Kim, S. H. Park, J. H. Lee, H. T. Jung, K. H. Chai, Y. G. |
| Description | Author Affiliation: Kim SK ( Division of Molecular and Life Science, Hanyang University, Ansan, Korea.) |
| Abstract | AIMS: For the analysis of virulence factors produced and secreted by Bacillus anthracis vegetative cells during mammalian host infection, we evaluated the secretome of B. anthracis Sterne exposed to host-specific factors specifically to host body temperature. METHODS AND RESULTS: We employed a comparative proteomics-based approach to analyse the proteins secreted by B. anthracis Sterne under host-specific body temperature conditions. A total of 17 proteins encoded on a single chromosome and the pXO1 plasmid were identified by peptide mass fingerprinting. Multiple algorithms were used to predict the secretion mechanisms of the detected proteins in B. anthracis. CONCLUSIONS: Several putative virulence factors and known factors responsible for sporulation were differentially regulated, including CodY, pXO1-130 and BA1952, revealing insights into temperature cues in the B. anthracis secretome. SIGNIFICANCE AND IMPACT OF THE STUDY: This study identified temperature-regulated proteins. Further studies aimed at understanding the physical and functional roles of these proteins in infection and control by elevated temperatures will contribute to detection, diagnostics and prophylaxis. |
| File Format | HTM / HTML |
| ISSN | 02668254 |
| Issue Number | 4 |
| Volume Number | 54 |
| e-ISSN | 1472765X |
| Journal | Letters in Applied Microbiology |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2012-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Microbiology Anthrax Microbiology Bacillus Anthracis Physiology Pathogenicity Bacterial Proteins Analysis Virulence Factors Classification Genetics Metabolism Body Temperature Humans Proteomics Virulence Comparative Study Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Applied Microbiology and Biotechnology |
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