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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sharifnia, A. Bakhshi, B. Pourshafie, M. R. |
| Spatial Coverage | Iran |
| Description | Country affiliation: Iran Author Affiliation: Sharifnia A ( Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.) |
| Abstract | AIMS: To investigate the molecular basis for serotype variation in Vibrio cholerae O1 and the genetic relatedness amongst different serotypes isolated from 2004 to 2008 in Iran. METHODS AND RESULTS: Despite the presence of all three serotypes of V.cholerae O1 (Ogawa, Inaba and Hikojima) in Iran in the last decade, the Inaba strains have been the dominated serotype. Sequence analysis of wbeT determined only a single substitution of G for A at position 295 in all Inaba strains resulting in a replacement of serine to proline. No difference was found in the copy numbers and profile of IS1004 between the classical and El Tor V. cholerae O1 strains, supporting the clonality amongst the isolates obtained over 5 years in Iran. In addition, Southern blots of HpaII-digested chromosomal DNAs of our Ogawa and Inaba isolates showed the presence of an incomplete copy of IS1004 for all isolates. CONCLUSIONS: IS1004 profiling can be a reliable method for analysis of clonal dissemination of V. cholerae. The results indicated that specific point mutation at a particular position within the wbeT of V. cholerae O1 strains in Iran may occur which, in turn, may result in serotype switching. SIGNIFICANCE AND IMPACT OF THE STUDY: Understanding the molecular basis for serotype conversion of V. cholerae and their genetic relatedness could give insights for the incoming cholera epidemic prediction and control. |
| File Format | HTM / HTML |
| ISSN | 02668254 |
| Issue Number | 4 |
| Volume Number | 54 |
| e-ISSN | 1472765X |
| Journal | Letters in Applied Microbiology |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2012-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Microbiology Cholera Microbiology Serotyping Methods Vibrio Cholerae Classification Genetics Epidemiology Disease Outbreaks Humans Iran Molecular Sequence Data Isolation & Purification Vibrio Cholerae O1 Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Applied Microbiology and Biotechnology |
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