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Topical anti-inflammatory activity of Eugenia brasiliensis Lam. (Myrtaceae) leaves.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pietrovski, Evelise Fernandes Magina, Michele Debiasi Alberton Gomig, Franciane Pietrovski, Caroline Fernandes Micke, Gustavo Amadeu Barcellos, Michele Pizzolatti, Moacir Geraldo Cabrini, Daniela Almeida Brighente, Inês Maria Costa Otuki, Michel Fleith
Spatial Coverage	Brazil
Description	Country affiliation: Brazil Author Affiliation: Pietrovski EF ( Laboratório de Inflamação, Dor e Febre, Departamento de Farmacologia, Setor de Ciências Biológicas, Universidade Federal do Paraná, Centro Politécnico, Curitiba, PR, Brazil.)
Abstract	Eugenia brasiliensis Lam., a plant from the south of Brazil, is used in the popular medicine for rheumatism treatment. This study reports that topical application of hydroalcoholic extract, fractions and isolated compounds from E. brasiliensis caused an inhibition of ear oedema in response to topical application of croton oil on the mouse ear. For oedema inhibition, the estimated ID50 values (dose reducing the inflammatory response by 50% relative to the control value) for hydroalcoholic extract and fractions (hexane, ethyl acetate and dichloromethane) were 0.17, 0.29, 0.13 and 0.14 mg/ear, respectively, with inhibition of 79+/-7%, 87+/-6%, 88+/-5% and 96+/-2%, respectively. Isolated phenolic compounds (quercetin, catechin and gallocatechin) were also effective in inhibiting the oedema (inhibition of 61+/-5%, 66+/-2% and 37+/-9%, respectively). Moreover, both extract and isolated compounds caused inhibition of polymorphonuclear cells influx (inhibition of 85+/-6%, 81+/-5%, 73+/-6% and 76+/-6%, respectively). The histological analysis of the ear tissue clearly confirmed that the extract and compounds of E. brasiliensis inhibited the influx of polymorphonuclear cells to mouse ear skin after application of croton oil. Furthermore, hydroalcoholic extract was also effective in inhibiting the arachidonic acid-mediated mouse ear oedema (ID50 value was 1.94 mg/ear and inhibition of 60+/-7%). Therefore, these results consistently support the notion that E. brasiliensis possesses topical anti-inflammatory activity.
File Format	HTM / HTML
ISSN	00223573
Issue Number	4
Volume Number	60
e-ISSN	20427158
Journal	Journal of Pharmacy and Pharmacology
Language	English
Publisher	Wiley
Publisher Date	2008-04-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Anti-inflammatory Agents, Non-steroidal Therapeutic Use Plant Leaves Chemistry Eugenia Administration, Topical Animals Isolation & Purification Antioxidants Arachidonic Acid Brazil Catechin Analogs & Derivatives Croton Oil Dermatitis Drug Therapy Etiology Dose-response Relationship, Drug Edema Chemically Induced Electrophoresis, Capillary Male Mice Phytotherapy Plant Extracts Quercetin Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmaceutical Science

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