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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kang, Ki Sung Yamabe, Noriko Kim, Hyun Young Yokozawa, Takako |
| Description | Country affiliation: Japan Author Affiliation: Kang KS ( Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.) |
| Abstract | Inhibitors of advanced glycation end products (AGEs) have potential as preventive agents against diabetic complications. In-vitro AGE inhibitory activity, transition metal chelating, and free radical scavenging activity tests have been used to screen for and identify effective AGE inhibitors. In an ongoing project to elucidate AGE inhibiting active components of heat-processed ginseng, maltol was selected for more detailed investigation. Although there are several lines of evidence concerning the antioxidant activity of maltol, the in-vitro and in-vivo inhibitory effects of maltol on AGE generation have not been evaluated. In the present study, the in-vitro AGE inhibitory effects and free radical scavenging activity of maltol were investigated. In addition, the in-vivo therapeutic potential of maltol against diabetic renal damage was tested using streptozotocin (STZ)-diabetic rats. Maltol showed a stronger AGE inhibitory effect than aminoguanidine, a well known AGE inhibitor. In addition, the hydroxyl radical scavenging activity of maltol on electron spin resonance (ESR) spectrometry was slightly stronger than that of aminoguanidine. Therefore, maltol was found to have stronger in-vitro AGE inhibiting activity compared with aminoguanidine. The administration of 50 mgkg(-1) per day of maltol suppressed the elevated serum levels of glycosylated protein, renal fluorescent AGEs, carboxymethyllysine, receptors for AGEs, and nuclear factor-kappaB p65 in diabetic control rats. These beneficial effects of maltol against STZ-diabetic renal damage were thought to result from its free radical scavenging and AGE inhibitory effects. |
| File Format | HTM / HTML |
| ISSN | 00223573 |
| Issue Number | 4 |
| Volume Number | 60 |
| e-ISSN | 20427158 |
| Journal | Journal of Pharmacy and Pharmacology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2008-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Free Radical Scavengers Pharmacology Glycosylation End Products, Advanced Metabolism Pyrones Advanced Glycosylation End Product-specific Receptor Animals Blood Glucose Analysis Creatinine Blood Diabetes Mellitus, Experimental Complications Drug Therapy Diabetic Nephropathies Etiology Prevention & Control Electron Spin Resonance Spectroscopy Administration & Dosage Chemistry Free Radicals Antagonists & Inhibitors Guanidines Lysine Analogs & Derivatives Drug Effects Male Proteinuria Rats Rats, Wistar Receptors, Immunologic Serum Albumin Streptozocin Transcription Factor Rela Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmaceutical Science |
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