NDLI: Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects.

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Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects.

Year: 2008 Volume: 11 Issue: 1

Year: 2007 Volume: 10

Year: 2000 Volume: 3

Year: 1999 Volume: 2

Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Seeram, Navindra P. Zhang, Yanjun McKeever, Rodney Henning, Susanne M. Lee, Ru-po Suchard, Marc A. Li, Zhaoping Chen, Steve Thames, Gail Zerlin, Alona Nguyen, Martha Wang, David Dreher, Mark Heber, David
Description	Country affiliation: United States Author Affiliation: Seeram NP ( Center for Human Nutrition, David Geffen School of Medicine, Los Angeles California, USA.)
Abstract	Pomegranate juice (PJ), a rich source of polyphenols including ellagitannins, has attracted much attention due to its reported health benefits. This has resulted in the consumption of liquid and powder pomegranate extracts as alternatives to PJ. Therefore establishing the bioavailability of polyphenols from these extract preparations is necessary. Sixteen healthy volunteers sequentially consumed, with a 1-week washout period between treatments, PJ (8 ounces, Wonderful fruit variety), a pomegranate polyphenol liquid extract (POMxl, 8 ounces), and a pomegranate polyphenol powder extract (POMxp, 1,000 mg). The three interventions provided 857, 776, and 755 mg of polyphenols as gallic acid equivalents, respectively. Plasma bioavailability, judged based on ellagic acid levels over a 6-hour period, did not show statistical differences in area under the curve for the three interventions: 0.14 +/- 0.05, 0.11 +/- 0.03, and 0.11 +/- 0.04 micromol . hour/L for PJ, POMxl, and POMxp, respectively. The time of maximum concentration was delayed for POMxp (2.58 +/- 0.42 hours) compared to PJ (0.65 +/- 0.23 hours) and POMxl (0.94 +/- 0.06 hours). Urolithin-A glucuronide, a urinary metabolite of ellagic acid, was not significantly different with the three interventions, reaching levels of approximately 1,000 ng/mL. This study demonstrates that ellagitannin metabolites, delivered from pomegranate fruits, as PJ, POMxl, and POMxp, reach equivalent levels with a delay in time of maximum concentration of POMxp compared to PJ and POMxl.
File Format	HTM / HTML
ISSN	1096620X
e-ISSN	15577600
DOI	10.1089/jmf.2007.650
Journal	Journal of Medicinal Food
Issue Number	2
Volume Number	11
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2008-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Nutritional Sciences Beverages Chemistry Hydrolyzable Tannins Pharmacokinetics Plant Extracts Administration & Dosage Punicaceae Biological Availability Coumarins Urine Diet Ellagic Acid Blood Flavonoids Kinetics Phenols Polyphenols Comparative Study Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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