NDLI: Antidiabetes and antihypertension potential of commonly consumed carbohydrate sweeteners using in vitro models.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ranilla, Lena Galvez Kwon, Young-In Genovese, Maria Ines Lajolo, Franco Maria Shetty, Kalidas
Description	Country affiliation: Brazil Author Affiliation: Ranilla LG ( Laboratório de Química, Bioquímica e Biologia Molecular de Alimentos, Departamento de Alimentos e Nutrição Experimental, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, Brazil.)
Abstract	Commonly consumed carbohydrate sweeteners derived from sugar cane, palm, and corn (syrups) were investigated to determine their potential to inhibit key enzymes relevant to Type 2 diabetes and hypertension based on the total phenolic content and antioxidant activity using in vitro models. Among sugar cane derivatives, brown sugars showed higher antidiabetes potential than white sugars; nevertheless, no angiotensin I-converting enzyme (ACE) inhibition was detected in both sugar classes. Brown sugar from Peru and Mauritius (dark muscovado) had the highest total phenolic content and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, which correlated with a moderate inhibition of yeast alpha-glucosidase without showing a significant effect on porcine pancreatic alpha-amylase activity. In addition, chlorogenic acid quantified by high-performance liquid chromatography was detected in these sugars (128 +/- 6 and 144 +/- 2 microg/g of sample weight, respectively). Date sugar exhibited high alpha-glucosidase, alpha-amylase, and ACE inhibitory activities that correlated with high total phenolic content and antioxidant activity. Neither phenolic compounds or antioxidant activity was detected in corn syrups, indicating that nonphenolic factors may be involved in their significant ability to inhibit alpha-glucosidase, alpha-amylase, and ACE. This study provides a strong biochemical rationale for further in vivo studies and useful information to make better dietary sweetener choices for Type 2 diabetes and hypertension management.
File Format	HTM / HTML
ISSN	1096620X
Issue Number	2
Volume Number	11
e-ISSN	15577600
Journal	Journal of Medicinal Food
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2008-06-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Nutritional Sciences Antihypertensive Agents Pharmacology Carbohydrates Hypoglycemic Agents Sweetening Agents Angiotensin-converting Enzyme Inhibitors Antioxidants Analysis Chlorogenic Acid Diabetes Mellitus, Type 2 Enzymology Enzyme Inhibitors Glycoside Hydrolase Inhibitors Phenols Placental Lactogen Alpha-amylases Antagonists & Inhibitors Journal Article
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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