| Author |
Lim, Jae-Sung Oh, Mi Sun Lee, Ju-Hun Jung, San Kim, Chulho Jang, Min Uk Lee, Sang-Hwa Kim, Yeo Jin Kim, Yerim Park, Jaeseol Kang, Yeonwook Yu, Kyung-Ho Lee, Byung-Chul |
| Description |
Author Affiliation: Lim JS ( Department of Neurology,Hallym Neurological Institute,Hallym University College of Medicine,Anyang,Republic of Korea.); Oh MS ( Department of Neurology,Hallym Neurological Institute,Hallym University College of Medicine,Anyang,Republic of Korea.); Lee JH ( Department of Neurology,Hallym Neurological Institute,Hallym University College of Medicine,Anyang,Republic of Korea.); Jung S ( Department of Neurology,Hallym Neurological Institute,Hallym University College of Medicine,Anyang,Republic of Korea.); Kim C ( Department of Neurology,Hallym Neurological Institute,Hallym University College of Medicine,Anyang,Republic of Korea.); Jang MU ( Department of Neurology,Hallym Neurological Institute,Hallym University College of Medicine,Anyang,Republic of Korea.); Lee SH ( Department of Neurology,Hallym Neurological Institute,Hallym University College of Medicine,Anyang,Republic of Korea.); Kim YJ ( Department of Neurology,Hallym Neurological Institute,Hallym University College of Medicine,Anyang,Republic of Korea.); Kim Y ( Department of Neurology,Hallym Neurological Institute,Hallym University College of Medicine,Anyang,Republic of Korea.); Park J ( Department of Neurology,Hallym Neurological Institute,Hallym University College of Medicine,Anyang,Republic of Korea.); Kang Y ( Department of Psychology,Hallym University College of Social Sciences,Chuncheon,Republic of Korea.); Yu KH ( Department of Neurology,Hallym Neurological Institute,Hallym University College of Medicine,Anyang,Republic of Korea.); Lee BC ( Department of Neurology,Hallym Neurological Institute,Hallym University College of Medicine,Anyang,Republic of Korea.) |
| Abstract |
BACKGROUND: The National Institute of Neurological Disease and Stroke-Canadian Stroke Network (NINDS-CSN) 5-minute neuropsychology protocol consists of only verbal tasks, and is proposed as a brief screening method for vascular cognitive impairment. We evaluated its feasibility within two weeks after stroke and ability to predict the development of post-stroke dementia (PSD) at 3 months after stroke. METHOD: We prospectively enrolled subjects with ischemic stroke within seven days of symptom onset who were consecutively admitted to 12 university hospitals. Neuropsychological assessments using the NINDS-CSN 5-minute and 60-minute neuropsychology protocols were administered within two weeks and at 3 months after stroke onset, respectively. PSD was diagnosed with reference to the American Heart Association/American Stroke Association statement, requiring deficits in at least two cognitive domains. RESULTS: Of 620 patients, 512 (82.6%) were feasible for the NINDS-CSN 5-minute protocol within two weeks after stroke. The incidence of PSD was 16.2% in 308 subjects who had completed follow-up at 3 months after stroke onset. The total score of the NINDS-CSN 5-minute protocol differed significantly between those with and without PSD (4.0 ± 2.7, 7.4 ± 2.7, respectively; p < 0.01). A cut-off value of 6/7 showed reasonable discriminative power (sensitivity 0.82, specificity 0.67, AUC 0.74). The NINDS-CSN 5-minute protocol score was a significant predictor for PSD (adjusted odds ratio 6.32, 95% CI 2.65-15.05). DISCUSSION: The NINDS-CSN 5-minute protocol is feasible to evaluate cognitive functions in patients with acute ischemic stroke. It might be a useful screening method for early identification of high-risk groups for PSD. |
