NDLI: Purple carrot anthocyanins suppress lipopolysaccharide-induced inflammation in the co-culture of intestinal Caco-2 and macrophage RAW264.7 cells

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Purple carrot anthocyanins suppress lipopolysaccharide-induced inflammation in the co-culture of intestinal Caco-2 and macrophage RAW264.7 cells

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Purple carrot anthocyanins suppress lipopolysaccharide-induced inflammation in the co-culture of intestinal Caco-2 and macrophage RAW264.7 cells

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Olejnik, Anna Kowalska, Katarzyna Kidon, Marcin Czapski, Janusz Rychlik, Joanna Olkowicz, Mariola Dembczynski, Radoslaw
Description	Author Affiliation: Olejnik A ( Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, Wojska Polskiego 48, 60-627 Poznan, Poland. aolejnik@up.poznan.pl kaskakow@up.poznan.pl joanna.rychlik@up.poznan.pl mariola.olkowicz@up.poznan.pl rdembcz@up.poznan.pl.); Kowalska K ( Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, Wojska Polskiego 48, 60-627 Poznan, Poland. aolejnik@up.poznan.pl kaskakow@up.poznan.pl joanna.rychlik@up.poznan.pl mariola.olkowicz@up.poznan.pl rdembcz@up.poznan.pl.); Kidon M ( Institute of Food Technology of Plant Origin, Poznan University of Life Sciences, Wojska Polskiego 31, Poznan 60-624, Poland. kidon@up.poznan.pl czapski@up.poznan.pl.); Czapski J ( Institute of Food Technology of Plant Origin, Poznan University of Life Sciences, Wojska Polskiego 31, Poznan 60-624, Poland. kidon@up.poznan.pl czapski@up.poznan.pl.); Rychlik J ( Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, Wojska Polskiego 48, 60-627 Poznan, Poland. aolejnik@up.poznan.pl kaskakow@up.poznan.pl joanna.rychlik@up.poznan.pl mariola.olkowicz@up.poznan.pl rdembcz@up.poznan.pl.); Olkowicz M ( Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, Wojska Polskiego 48, 60-627 Poznan, Poland. aolejnik@up.poznan.pl kaskakow@up.poznan.pl joanna.rychlik@up.poznan.pl mariola.olkowicz@up.poznan.pl rdembcz@up.poznan.pl.); Dembczynski R ( Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, Wojska Polskiego 48, 60-627 Poznan, Poland. aolejnik@up.poznan.pl kaskakow@up.poznan.pl joanna.rychlik@up.poznan.pl mariola.olkowicz@up.poznan.pl rdembcz@up.poznan.pl.)
Abstract	This study was designed to evaluate the anti-inflammatory effects of purple carrot anthocyanins (PCA) with respect to gut inflammation, simulated in a co-culture system consisting of intestinal epithelial Caco-2 cells and RAW264.7 macrophages. The obtained results indicated that PCA extract down-regulates the mRNA expression of proinflammatory interleukins Il-1β (↓91%) and Il-6 (↓69%) as well as inflammatory mediators, such as cyclooxygenase-2 (Cox-2) and inducible nitric oxide synthase (iNos), in lipopolysaccharide-activated RAW264.7 cells. The decrease in the generation of prostaglandin $E_{2}$ (↓48%) and nitric oxide (↓26%) was observed as a result of the inhibition of Cox-2 (↓25%) and iNos (↓12%) mRNA expressions, respectively. Moreover, the PCA reduced mRNA expression (↓40%) and production (↓17%) of IL-8 in intestinal cells. The anti-inflammatory effect of PCA was contributed to the protection of the intestinal barrier, which was disrupted upon the stimulation of macrophages. These findings may provide preliminary justification for the use of PCA in further studies focused on the prevention and therapy supporting the conventional treatment of inflammatory bowel diseases.
File Format	HTM / HTML
ISSN	20426496
Issue Number	1
Volume Number	7
e-ISSN	2042650X
Journal	Food & Function
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2016-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Physiology Discipline Biochemistry Discipline Chemistry Discipline Nutritional Sciences Anthocyanins Pharmacology Daucus Carota Chemistry Inflammation Chemically Induced Lipopolysaccharides Toxicity Macrophages Drug Effects Animals Biological Transport Caco-2 Cells Cell Line Coculture Techniques Humans Drug Therapy Mice Permeability Plant Extracts Raw 264.7 Cells Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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