NDLI: Acutely administered grape-seed proanthocyanidin extract acts as a satiating agent

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Serrano, Joan Casanova-Martí, Àngela Gil-Cardoso, Katherine Blay, M. Teresa Terra, Ximena Pinent, Montserrat Ardévol, Anna
Description	Country affiliation: Spain Author Affiliation: Serrano J ( Universitat Rovira i Virgili, Biochemistry and Biotechnology Department, c/Marcel lí Domingo no. 1, 43007, Tarragona, Spain. montserrat.pinent@urv.cat.); Casanova-Martí À ( Universitat Rovira i Virgili, Biochemistry and Biotechnology Department, c/Marcel lí Domingo no. 1, 43007, Tarragona, Spain. montserrat.pinent@urv.cat.); Gil-Cardoso K ( Universitat Rovira i Virgili, Biochemistry and Biotechnology Department, c/Marcel lí Domingo no. 1, 43007, Tarragona, Spain. montserrat.pinent@urv.cat.); Blay MT ( Universitat Rovira i Virgili, Biochemistry and Biotechnology Department, c/Marcel lí Domingo no. 1, 43007, Tarragona, Spain. montserrat.pinent@urv.cat.); Terra X ( Universitat Rovira i Virgili, Biochemistry and Biotechnology Department, c/Marcel lí Domingo no. 1, 43007, Tarragona, Spain. montserrat.pinent@urv.cat.); Pinent M ( Universitat Rovira i Virgili, Biochemistry and Biotechnology Department, c/Marcel lí Domingo no. 1, 43007, Tarragona, Spain. montserrat.pinent@urv.cat.); Ardévol A ( Universitat Rovira i Virgili, Biochemistry and Biotechnology Department, c/Marcel lí Domingo no. 1, 43007, Tarragona, Spain. montserrat.pinent@urv.cat.)
Abstract	Grape-seed proanthocyanidins’ role as stimulators of active GLP-1 in rats suggests that they could be effective as satiating agents. Wistar rats were used to study the effects of proanthocyanidins on food intake with different doses, administration times and proanthocyanidin extract compositions. A dose of 423 mg of phenolics per kg body weight (BW) of grape-seed proanthocyanidin extract (GSPE) was necessary to decrease the 12-hour cumulative food intake by 18.7 ± 3.4%. Proanthocyanidins were effective when delivered directly into the gastrointestinal tract one hour before, or simultaneously at the start of the feeding period. Proanthocyanidins without galloyl forms, such as those from cocoa extract, were not as effective as grape-seed derived forms. GSPE increased the portal levels of active GLP-1 and total ghrelin and decreased the CCK levels, simultaneously with a decrease in gastric emptying. In conclusion, grape-seed proanthocyanidins could be useful as a satiating agent under the conditions defined in this study.
File Format	HTM / HTML
ISSN	20426496
Issue Number	1
Volume Number	7
e-ISSN	2042650X
Journal	Food & Function
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2016-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Physiology Discipline Biochemistry Discipline Chemistry Discipline Nutritional Sciences Grape Seed Extract Pharmacology Proanthocyanidins Satiety Response Drug Effects Animals Body Weight Cross-over Studies Eating Female Gene Expression Regulation Chemistry Male Random Allocation Rats Rats, Wistar Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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