NDLI: Ischemic heart disease and stroke in relation to blood DNA methylation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Baccarelli, Andrea Wright, Robert Bollati, Valentina Litonjua, Augusto Zanobetti, Antonella Tarantini, Letizia Sparrow, David Vokonas, Pantel Schwartz, Joel
Spatial Coverage	Boston
Description	Country affiliation: Italy Author Affiliation: Baccarelli A ( Center of Molecular and Genetic Epidemiology, Università degli Studi di Milano & IRCCS Ca', Granda Policlinico Maggiore Hospital Foundation, Milan, Italy. abaccare@hsph.harvard.edu)
Abstract	BACKGROUND: Epigenetic features such as DNA hypomethylation have been associated with conditions related to cardiovascular risk. We evaluated whether lower blood DNA methylation in heavily methylated repetitive sequences predicts the risk of ischemic heart disease and stroke. METHODS: We quantified blood DNA methylation of Long Interspersed Nucleotide Element-1 (LINE-1) repetitive elements through PCR-pyrosequencing in 712 elderly individuals from the Boston-area Normative Aging Study. We estimated risk-factor adjusted relative risks (RRs) for ischemic heart disease and stroke at baseline (242 prevalent cases), and during follow-up (44 new cases; median follow-up, 63 months), as well as subsequent mortality from ischemic heart disease (86 deaths; median follow-up, 75 months). RESULTS: Blood LINE-1 hypomethylation was associated with baseline ischemic heart disease (RR = 2.1 [95% confidence interval = 1.2-4.0] for lowest vs. highest methylation quartile) and for stroke (2.5 [0.9-7.5]). Among participants free of baseline disease, individuals with methylation below the median also had higher risk of developing ischemic heart disease (4.0 [1.8-8.9]) or stroke (5.7 [0.8-39.5]). In the entire cohort, persons with methylation below the median had higher mortality from ischemic heart disease (3.3 [1.3-8.4]) and stroke (2.8 [0.6-14.3]). Total mortality was also increased (2.0 [1.2-3.3]). These results were confirmed in additional regression models using LINE-1 methylation as a continuous variable. CONCLUSIONS: Subjects with prevalent IHD and stroke exhibited lower LINE-1 methylation. In longitudinal analyses, persons with lower LINE-1 methylation were at higher risk for incident ischemic heart disease and stroke, and for total mortality.
File Format	HTM / HTML
ISSN	10443983
e-ISSN	15315487
DOI	10.1097/EDE.0b013e3181f20457
Journal	Epidemiology
Issue Number	6
Volume Number	21
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2010-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Public Health Discipline Epidemiology Dna Methylation Long Interspersed Nucleotide Elements Genetics Myocardial Ischemia Stroke Boston Epidemiology Cross-sectional Studies Mortality Polymerase Chain Reaction Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Epidemiology

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