NDLI: Arsenic exposure and risk of spontaneous abortion, stillbirth, and infant mortality.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rahman, Anisur Persson, Lars-Åke Nermell, Barbro El Arifeen, Shams Ekström, Eva-Charlotte Smith, Allan H. Vahter, Marie
Spatial Coverage	Bangladesh
Description	Country affiliation: Bangladesh Author Affiliation: Rahman A ( International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. anisur.rahman@kbh.uu.se)
Abstract	BACKGROUND: Millions of people worldwide are drinking water with elevated arsenic concentrations. Epidemiologic studies, mainly cross-sectional in design, have suggested that arsenic in drinking water may affect pregnancy outcome and infant health. We assessed the association of arsenic exposure with adverse pregnancy outcomes and infant mortality in a prospective cohort study of pregnant women. METHODS: A population-based, prospective cohort study of 2924 pregnant women was carried out during 2002-2004 in Matlab, Bangladesh. Spontaneous abortion was evaluated in relation to urinary arsenic concentrations at gestational week 8. Stillbirth and infant mortality were evaluated in relation to the average of urinary arsenic concentrations measured at gestational weeks 8 and 30. RESULTS: : The odds ratio of spontaneous abortion was 1.4 (95% confidence interval [CI] = 0.96-2.2) among women with urine arsenic concentrations in the fifth quintile (249-1253 µg/L; median = 382 µg/L), compared with women in the first quintile (<33 µg/L). There was no clear evidence of increased rates of stillbirth. The rate of infant mortality increased with increasing arsenic exposure: the hazard ratio was 5.0 (95% CI = 1.4-18) in the fifth quintile of maternal urinary arsenic concentrations (268-2019 µg/L; median = 390 µg/L), compared with the first quintile (<38 µg/L). CONCLUSIONS: We found evidence of increased risk of infant mortality with increasing arsenic exposure during pregnancy, with less evidence of associations with spontaneous abortion or stillbirth risk.
File Format	HTM / HTML
ISSN	10443983
Issue Number	6
Volume Number	21
e-ISSN	15315487
Journal	Epidemiology
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2010-11-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Public Health Discipline Epidemiology Abortion, Spontaneous Chemically Induced Arsenic Toxicity Environmental Pollutants Infant Mortality Stillbirth Epidemiology Bangladesh Female Humans Infant, Newborn Population Surveillance Prospective Studies Journal Article Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Epidemiology

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