NDLI: Disturbed Th1, Th2, Th17 and T(reg) balance in patients with systemic lupus erythematosus.

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Disturbed Th1, Th2, Th17 and T(reg) balance in patients with systemic lupus erythematosus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dolff, Sebastian Bijl, Marc Huitema, Minke G. Limburg, Pieter C. Kallenberg, Cees G. M. Abdulahad, Wayel H.
Description	Country affiliation: Netherlands Author Affiliation: Dolff S ( Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, The Netherlands. Sebastian.Dolff@uk-essen.de)
Abstract	Systemic lupus erythematosus (SLE) is an autoimmune disease accompanied by disturbed T-cell homeostasis. Dysbalance of T-helper-cell (Th) subsets (Th1/Th2/Th17) and regulatory T-cells (T(regs)) is suggested to contribute to the pathogenesis of SLE. Recent reports suggest functional deviation of T(regs) in terms of producing IL-17A, a process that may be aberrant in SLE. Therefore, we analyzed these T-cell subsets in SLE to test the hypothesis that aberrant T-cell subset skewing is present in SLE-patients. We investigated simultaneously the intracellular cytokines IFN-Î³, IL-4 and IL-17A in CD4(+)T-cells as well as in T(regs). Skewing of T-cell subsets towards Th17 cells was observed in SLE-patients. Although the proportion of T(regs) was similar between SLE-patients and healthy controls, the ability of T(regs) to express IFN-Î³ and IL17A was impaired in SLE-patients. Even in quiescent SLE-patients T-cell homeostasis is aberrant in terms of skewing towards IL-17 producing T-cells.
File Format	HTM / HTML
ISSN	15216616
Issue Number	2
Volume Number	141
e-ISSN	15217035
Journal	Clinical Immunology
Language	English
Publisher	Elsevier
Publisher Date	2011-11-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Lupus Erythematosus, Systemic Immunology T-lymphocyte Subsets Pathology T-lymphocytes, Regulatory Th1 Cells Th17 Cells Th2 Cells Adult Female Flow Cytometry Forkhead Transcription Factors Blood Homeostasis Humans Immunophenotyping Interferon-gamma Interleukin-17 Interleukin-4 Intracellular Fluid Chemistry Lymphocyte Count Male Middle Aged Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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