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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kumar, Sudhir Naqvi, Raza A. Khanna, Neena Pathak, Pankaj Rao, D. N. |
| Description | Author Affiliation: Kumar S ( Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi.) |
| Abstract | Leprosy is a chronic human disease; primarily affecting skin, peripheral nerves, eyes, testis etc. Comprehensive-expressional-profiling of Th1-Th2-Th3 associated markers (84 genes) using qRT-PCR array, negated the previously prevailing notion, Th2 bias towards multibacillary stage of leprosy. High production TGF-ß further supported the dearth of any immune response(s) in leprosy progression. Over expression of Cbl-b, could emerge as plausible reason for contributing T cell hyporesponsiveness, possibly by degradation of T cells signaling molecules. Anti-TGF-ß treatments further confirm the TGF-ß-dependent-Cbl-b overexpression in multibacillary patients. Diminished Cbl-b expression in CTLA-4 knockout studies using siRNA, provided other evidence towards T cell hyporesponsiveness. Further, high T cell proliferation and IL-2 production in PBMC cultures treated with anti-TGF-ß and siRNA offers here a strategy to revert T cell hyporesponsiveness by downregulating Cbl-b expression in leprosy. Thus, this study negates Th2 bias and substantiates molecular cross-talk amongst TGF-ß-CTLA-4-Cbl-b eventually leads to M. leprae persistence. |
| File Format | HTM / HTML |
| ISSN | 15216616 |
| Issue Number | 2 |
| Volume Number | 141 |
| e-ISSN | 15217035 |
| Journal | Clinical Immunology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology Adaptor Proteins, Signal Transducing Immunology Ctla-4 Antigen Gene Expression Profiling Leprosy, Multibacillary Leprosy, Paucibacillary Mycobacterium Leprae Proto-oncogene Proteins C-cbl T-lymphocytes, Regulatory Transforming Growth Factor Beta Biosynthesis Genetics Amino Acid Sequence Antibodies, Monoclonal Pharmacology Antigens, Bacterial Antagonists & Inhibitors Cell Lineage Cell Wall Cells, Cultured Cytokines Secretion Disease Progression Gene Expression Regulation Humans Immune Tolerance Immunity, Cellular Molecular Sequence Data Rna, Small Interfering Th1 Cells Th2 Cells Comparative Study Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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