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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chung, Wen Yuan Gravante, Gianpiero Al-Leswas, Dhya Arshad, Ali Sorge, Roberto Watson, Chris C. Pollard, Cristina Metcalfe, Matthew S. Dennison, Ashley R. |
| Description | Country affiliation: United kingdom Author Affiliation: Chung WY ( Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, University of Leicester, Leicester, UK.) |
| Abstract | We already developed an ex vivo liver-kidney model perfused for 6 h in which the kidney acted as a homeostatic organ to improve the circuit milieu compared to liver alone. In the current study, we extended the multiorgan perfusions to 24 h to evaluate the results and eventual pitfalls manifesting with longer durations. Five livers and kidneys were harvested from female pigs and perfused over 24 h. The extracorporeal circuit included a centrifugal pump, heat exchanger, and oxygenator. The primary end point of the study was the evaluation of the organ functions as gathered from biochemical and acid-base parameters. In the combined liver-kidney circuit, the organs survived and maintained an acceptable homeostasis for different lengths of time, longer for the liver (up to 19-23 h of perfusions) than the kidney (9-13 h of perfusions). Furthermore, glucose and creatinine values decreased significantly over time (from the 5th and 9th hour of perfusion onward). The addition of a kidney to the perfusion circuit improved the biochemical environment by removing excess products from ongoing metabolic processes. The consequence is a more physiological milieu that could improve results from future experimental studies. However, it is likely that long perfusions require some nutritional support over the hours to maintain the organ's vitality and functionality throughout the experiments. |
| File Format | HTM / HTML |
| ISSN | 0160564X |
| Issue Number | 5 |
| Volume Number | 37 |
| e-ISSN | 15251594 |
| Journal | Artificial Organs |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2013-05-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Transplantation Extracorporeal Membrane Oxygenation Kidney Blood Supply Liver Circulation Liver Perfusion Methods Renal Circulation Acid-base Equilibrium Animals Biological Markers Blood Glucose Metabolism Creatinine Blood Equipment Design Adverse Effects Instrumentation Female Homeostasis Hydrogen-ion Concentration Models, Animal Swine Time Factors Tissue Survival Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biomaterials Bioengineering Biomedical Engineering |
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