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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Koo, Ki-Hyoung Lee, Jong-Min Ahn, Jung-Min Kim, Byung-Soo La, Wan-Geun Kim, Chang-Sung Im, Gun-Il |
| Description | Author Affiliation: Koo KH ( Department of Orthopaedic Surgery, Dongguk University Ilsan Hospital, Goyang, Korea.) |
| Abstract | The heparin-conjugated fibrin (HCF) system has been developed to deliver bone morphogenetic proteins (BMPs) for a long-term period and thus enhance bone regeneration. In the present study, we tested the effectiveness of the delivery system for spinal fusion with a very low dose of BMP-2. A total of 15 rabbits underwent posterolateral lumbar spine, divided into three groups. The control group received only collagen sponges without BMP-2, another group (BMP-only group) received collagen sponges loaded with BMP-2 (10 µg each side), and the last group (BMP/HCF group) received collagen sponges filled with HCF loaded with BMP-2 (10 µg each side). All animals were euthanized 8 weeks after surgery, and the fusion was assessed by radiographs, manual palpation, computed tomography scan, and mechanical testing. No case in the BMP/HCF group or in the control group achieved solid fusion, while all cases in BMP-only group showed evidence of solid fusion. BMP/HCF group had significantly lower fusion rate and tensile strength than BMP-only group at the dose of 10 µg of BMP-2. The HCF long-term delivery system with the low dose of BMP-2 (10 µg) is ineffective for the induction of lumbar posterolateral fusion in the rabbits. |
| File Format | HTM / HTML |
| ISSN | 0160564X |
| Issue Number | 5 |
| Volume Number | 37 |
| e-ISSN | 15251594 |
| Journal | Artificial Organs |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2013-05-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Transplantation Bone Morphogenetic Protein 2 Administration & Dosage Bone Regeneration Drug Effects Drug Carriers Fibrin Chemistry Heparin Lumbar Vertebrae Surgery Spinal Fusion Surgical Sponges Animals Biomechanical Phenomena Delayed-action Preparations Humans Pathology Male Palpation Rabbits Tensile Strength Time Factors Tomography, X-ray Computed Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biomaterials Bioengineering Biomedical Engineering |
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