NDLI: ZP-binding peptides identified via phage display stimulate production of sperm antibodies in dogs.

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ZP-binding peptides identified via phage display stimulate production of sperm antibodies in dogs.

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ZP-binding peptides identified via phage display stimulate production of sperm antibodies in dogs.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Samoylova, Tatiana I. Cox, Nancy R. Cochran, Anna M. Samoylov, Alexandre M. Griffin, Brenda Baker, Henry J.
Description	Country affiliation: United States Author Affiliation: Samoylova TI ( Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, Auburn, AL 36830, USA. samoiti@auburn.edu)
Abstract	Zona pellucida (ZP) glycoproteins play a central role in sperm-oocyte binding and fertilization. Sperm protein sequences that are involved in sperm-ZP recognition and have an important role in fertilization represent attractive targets for development of contraceptive vaccines, yet are currently unknown. To identify peptide sequences that recognize and bind to ZP proteins, we developed a novel selection procedure from phage display libraries that utilizes intact oocytes surrounded by ZP proteins. The major advantage of this procedure is that ZP proteins remain in their native conformation unlike a selection protocol previously published that utilized solubilized ZP on artificial solid support. Several peptides of 7 and 12 amino acids with binding specificity to canine ZP proteins were identified. Four of them (LNSFLRS, SSWYRGA, YLPIYTIPSMVY, and NNQSPILKLSIH) plus a control ZP-binding peptide (YLPVGGLRRIGG) from the literature were synthesized and tested for antigenic properties in dogs. NNQSPILKLSIH peptide stimulated production of anti-peptide antibodies. These antibodies bind to the acrosomal region of the canine sperm cell, demonstrating ability to act as sperm antibodies. The identified ZP-binding peptides (mimicking sperm cell surface antigens) may be useful in the design of immunocontraceptive agents for dogs.
File Format	HTM / HTML
ISSN	03784320
Issue Number	1-4
Volume Number	120
e-ISSN	18732232
Journal	Animal Reproduction Science
Language	English
Publisher	Elsevier
Publisher Date	2010-07-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Animal science Discipline Reproductive Medicine Discipline Veterinary Medicine Discipline Zoology Antibody Formation Drug Effects Carrier Proteins Isolation & Purification Dogs Peptide Fragments Pharmacology Spermatozoa Immunology Zona Pellucida Metabolism Amino Acid Sequence Animals Antibodies Blood Antigens, Surface Analysis Chemistry Contraception, Immunologic Veterinary Physiology Egg Proteins Female Male Membrane Glycoproteins Peptide Library Receptors, Cell Surface Controlled Clinical Trial Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Animal Science and Zoology Endocrinology Food Animals

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ZP-binding peptides identified via phage display stimulate production of sperm antibodies in dogs.

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ZP-binding peptides identified via phage display stimulate production of sperm antibodies in dogs.