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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rezvani, Amir H. Kholdebarin, Ehsan Brucato, Frederic H. Callahan, Patrick M. Lowe, David A. Levin, Edward D. |
| Description | Country affiliation: United States Author Affiliation: Rezvani AH ( Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA. Azadi@duke.edu) |
| Abstract | It is well established that nicotinic systems in the brain are critically involved in attentional processes in both animals and humans. The current study assessed the effects of a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist, R3487/MEM3454 (also referred to as R3487 or MEM 3454) on sustained attention in rats performing an operant visual signal detection task. The effects of R3487/MEM3454 were compared to those of the acetylcholinesterase inhibitor/nicotinic alpha7 allosteric positive modulator galanthamine. Adult female Sprague-Dawley rats were injected subcutaneously with R3487/MEM3454 (0.03, 0.1, 0.15, 0.3 and 0.6 mg/kg), galanthamine (0.25, 0.5, 1, 2 mg/kg) or vehicle 30 min before the attentional test. In the second study, the time-dependent effects of R3487/MEM3454 were assessed by injecting the compound (0.6 mg/kg, s.c.) at different pretreatment intervals (30, 60 or 90 min) before the start of the attentional task. Our results show a significant dose-effect for R3487/MEM3454 on percent hit accuracy performance without any significant alteration on percent correct rejection performance. In the time-dependent test, R3487/MEM3454 significantly increased the percent hit accuracy performance when animals were injected 60 min before the start of the attentional task. Administration of galanthamine failed to significantly increase percent hit accuracy performance and increasing the dose of galanthamine produced a decrease in percent correct rejection performance. The present findings with R3487/MEM3454 suggest that nicotinic alpha7 receptors and/or 5-HT3 receptors may play an important role in modulating sustained attention and that R3487/MEM3454 may have therapeutic potential in improving sustained attention in humans. |
| File Format | HTM / HTML |
| ISSN | 02785846 |
| Issue Number | 2 |
| Volume Number | 33 |
| e-ISSN | 18784216 |
| Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-03-17 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Psychiatry Attention Drug Effects Nicotinic Agonists Pharmacology Receptors, Nicotinic Serotonin 5-ht3 Receptor Antagonists Serotonin Antagonists Animals Conditioning, Operant Dose-response Relationship, Drug Female Galantamine Nootropic Agents Psychomotor Performance Rats Rats, Sprague-dawley Signal Detection, Psychological Alpha7 Nicotinic Acetylcholine Receptor Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Pharmacology |
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