NDLI: No association of serotonin transporter polymorphism (5-HTTVNTR and 5-HTTLPR) with characteristics and treatment response to atypical antipsychotic agents in schizophrenic patients.

Please wait, while we are loading the content...

No association of serotonin transporter polymorphism (5-HTTVNTR and 5-HTTLPR) with characteristics and treatment response to atypical antipsychotic agents in schizophrenic patients.

The leukocytes expressing DARPP-32 are reduced in patients with schizophrenia and bipolar disorder.

On the association between low resting heart rate and chronic aggression: retinoid toxicity hypothesis.

Expression of neuronal calcium sensor-1 (NCS-1) is decreased in leukocytes of schizophrenia and bipolar disorder patients.

Brain glucose metabolism difference between bipolar and unipolar mood disorders in depressed and euthymic states.

Post-session injections of a protein synthesis inhibitor, cycloheximide do not alter saccharin self-administration.

Sex differences in corticolimbic dopamine and serotonin systems in the rat and the effect of postnatal handling.

Effect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats.

Effects of fluoxetine and venlafaxine on serum brain derived neurotrophic factor levels in depressed patients.

Functional correlates for 5-HT(1A) receptors in maternally deprived rats displaying anxiety and depression-like behaviors.

Tardive dyskinesia associated with long-term administration of escitalopram and itopride in major depressive disorder.

Effects of acute and chronic administration of MK-801 on c-Fos protein expression in mice brain regions implicated in schizophrenia with or without clozapine.

Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease.

Atypical antipsychotics suppress production of proinflammatory cytokines and up-regulate interleukin-10 in lipopolysaccharide-treated mice.

Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: a systematic review.

Charles Bonnet syndrome: successful treatment of visual hallucinations due to vision loss with Yi-gan san.

A prediction rule for diagnosing hypomania.

Chronic underactivity of medial frontal cortical beta2-containing nicotinic receptors increases clozapine-induced working memory impairment in female rats.

GABA and opioid mechanisms of the central amygdala underlie the withdrawal-potentiated startle from acute morphine.

Phenotype of spontaneous orofacial dyskinesia in neuregulin-1 'knockout' mice.

The involvement of serotonergic system in the antidepressant effect of zinc in the forced swim test.

Low serum BDNF and food intake regulation: a possible new explanation of the pathophysiology of eating disorders.

Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: animal and human studies.

Aripiprazole-induced sialorrhea.

SAT-1 -1415T/C polymorphism and susceptibility to schizophrenia.

Supersensitivity psychosis after tapering aripiprazole: a case report.

Evaluation of the effects of vitamin A supplementation on adult rat substantia nigra and striatum redox and bioenergetic states: mitochondrial impairment, increased 3-nitrotyrosine and alpha-synuclein, but decreased D2 receptor contents.

Safety and antipsychotic efficacy of 'forced' intramuscular olanzapine over five days: a case report.

Therapeutic effects of the selective serotonin noradrenaline reuptake inhibitor milnacipran on depressive symptoms in patients with Alzheimer's disease.

Anxiolytic-like effect of phytoestrogen genistein in rats with long-term absence of ovarian hormones in the black and white model.

Relative contribution of antipsychotics, negative symptoms and executive functions to social functioning in stable schizophrenia.

Correlation between lipid peroxidation-induced TBARS level and disease severity in obsessive-compulsive disorder.

Year: 2009 Volume: 33 Issue: 1

Year: 2008 Volume: 32

Year: 2007 Volume: 31

Year: 2005 Volume: 29

Year: 2001 Volume: 25

No association of serotonin transporter polymorphism (5-HTTVNTR and 5-HTTLPR) with characteristics and treatment response to atypical antipsychotic agents in schizophrenic patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lee, Hwa-Young Kim, Dai-Jin Lee, Heon-Jeong Choi, Jung-Eun Kim, Yong-Ku
Spatial Coverage	Korea
Description	Author Affiliation: Lee HY ( Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic of Korea.)
Abstract	BACKGROUND: Serotonin transporter is a candidate gene for the pathogenesis of some psychiatric disorders. The aim of this study was to examine the role of the serotonin transporter gene polymorphism in the clinical aspects of schizophrenia including symptomatology and therapeutic response. METHODS: This study comprised 141 unrelated patients who strictly met the DSM-IV criteria for schizophrenia and 115 control subjects. All subjects were of Korean ethnicity. Serotonin transporter intron 2 VNTR polymorphism (5-HTTVNTR) and serotonin transporter linked polymorphic region polymorphism (5-HTTLPR) were analyzed in schizophrenia patients and control subjects. The Positive and Negative Symptom Scale (PANSS) was used at baseline and 6 weeks after atypical antipsychotic treatment to evaluate the clinical symptoms. Body mass index (BMI), the Barnes Akathisia Rating Scale (BARS), the Simpson-Angus Rating Scale (EPS) for adverse effect and the Calgary Depression rating Scale for Schizophrenia (CDSS) were measured. RESULTS: There were no significant differences in the frequency of genotypes between schizophrenia patients and control subjects. There were no significant differences in PANSS scores before treatment according to the serotonin transporter genotypes. Treatment response after atypical antipsychotics did not differ among the genotypes. No difference was shown among the genotypes for the scales in adverse effects and depression (BMI, BARS, EPS, CDSS). CONCLUSIONS: Our results suggest that the serotonin transporter polymorphism does not seem to be a susceptibility factor for schizophrenia. Similarly, the serotonin transporter polymorphism might not affect the therapeutic response and adverse effect to atypical antipsychotics in Korean patients with schizophrenia. Further studies with a larger number of subjects are required to better understand the role of the serotonin transporter polymorphism in schizophrenia.
File Format	HTM / HTML
ISSN	02785846
Issue Number	2
Volume Number	33
e-ISSN	18784216
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Language	English
Publisher	Elsevier
Publisher Date	2009-03-17
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Psychiatry Antipsychotic Agents Therapeutic Use Schizophrenia Drug Therapy Genetics Serotonin Plasma Membrane Transport Proteins Adult Age Of Onset Body Mass Index Dna Female Gene Frequency Genotype Humans Korea Epidemiology Male Polymorphism, Genetic Psychiatric Status Rating Scales Psychomotor Agitation Psychology Reverse Transcriptase Polymerase Chain Reaction Schizophrenic Psychology Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Pharmacology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Evaluation of the 5-HTTLPR and 5-HTTVNTR Polymorphisms in the Serotonin Transporter Gene in Women with Postpartum Depression

Effects of depot neuroleptics on driving performance in chronic schizophrenic patients.

Olfactory hedonic judgment in patients with deficit syndrome schizophrenia.

Association of Anxiety Symptoms in Offspring of Bipolar Parents with Serotonin Transporter-Linked Polymorphic Region (5-HTTLPR) Genotype.

The PANSS should be rescaled.

Serotonin-1A receptor gene polymorphism and the ability of antipsychotic drugs to improve attention in schizophrenia.

The effects of antipsychotic drugs and symptomatology on perceptual asymmetry in schizophrenia.

Deficit schizophrenia: an overview of clinical, biological and treatment aspects.

Acute antipyschotic efficacy and side effects in schizophrenia: association with serotonin transporter promoter genotypes.

No association of serotonin transporter polymorphism (5-HTTVNTR and 5-HTTLPR) with characteristics and treatment response to atypical antipsychotic agents in schizophrenic patients.

Similar Documents

Evaluation of the 5-HTTLPR and 5-HTTVNTR Polymorphisms in the Serotonin Transporter Gene in Women with Postpartum Depression

Effects of depot neuroleptics on driving performance in chronic schizophrenic patients.

Olfactory hedonic judgment in patients with deficit syndrome schizophrenia.

Association of Anxiety Symptoms in Offspring of Bipolar Parents with Serotonin Transporter-Linked Polymorphic Region (5-HTTLPR) Genotype.

The PANSS should be rescaled.

Serotonin-1A receptor gene polymorphism and the ability of antipsychotic drugs to improve attention in schizophrenia.

The effects of antipsychotic drugs and symptomatology on perceptual asymmetry in schizophrenia.

Deficit schizophrenia: an overview of clinical, biological and treatment aspects.

Acute antipyschotic efficacy and side effects in schizophrenia: association with serotonin transporter promoter genotypes.

No association of serotonin transporter polymorphism (5-HTTVNTR and 5-HTTLPR) with characteristics and treatment response to atypical antipsychotic agents in schizophrenic patients.