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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Briscione, Maria A. Serafine, Katherine M. Merluzzi, Andrew P. Rice, Kenner C. Riley, Anthony L. |
| Description | Country affiliation: United States Author Affiliation: Briscione MA ( Psychopharmacology Laboratory, Department of Psychology, American University, Washington, DC 20016, United States. mariabriscione@gmail.com) |
| Abstract | Although cocaine readily induces taste aversions, little is known about the mechanisms underlying this effect. Recent work has shown that cocaine's actions on serotonin (5-HT) may be involved. To address this possibility, the present experiments examined a role of the specific 5-HT receptor, 5-HT3, in this effect given that it is implicated in a variety of behavioral effects of cocaine. This series of investigations first assessed the aversive effects of the 5-HT3 receptor antagonist tropisetron alone (Experiment 1). Specifically, in Experiment 1 male Sprague-Dawley rats were given repeated pairings of a novel saccharin solution and tropisetron (0, 0.056, 0.18 and 0.56mg/kg). Following this, a non-aversion-inducing dose of tropisetron (0.18mg/kg) was assessed for its ability to block aversions induced by a range of doses of cocaine (Experiment 2). Specifically, in Experiment 2 animals were given access to a novel saccharin solution and then injected with tropisetron (0 or 0.18mg/kg) followed by an injection of various doses of cocaine (0, 10, 18 and 32mg/kg). Cocaine induced dose-dependent taste aversions that were not blocked by tropisetron, suggesting that cocaine's aversive effects are not mediated by 5-HT, at least at this specific receptor subtype. At the intermediate dose of cocaine, aversions appeared to be potentiated, suggesting 5-HT3 may play a limiting role in cocaine's aversive effects. These data are discussed in the context of previous examinations of the roles of serotonin, dopamine, and norepinephrine in cocaine-induced aversions. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| e-ISSN | 18735177 |
| DOI | 10.1016/j.pbb.2013.02.003 |
| Journal | Pharmacology Biochemistry and Behavior |
| Volume Number | 105 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Avoidance Learning Conditioning, Operant Indoles Pharmacology Receptors, Serotonin, 5-ht3 Drug Effects Taste Animals Rats, Sprague-dawley Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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