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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wu, Hsin-I Chang, Yun-Hsuan Lai, Chun-Chieh Wu, Jo Yung-Wei Chen, Shiou-Lan Chu, Chun-Hsien Lee, I. Hui Yeh, Tzung Lieh Tzeng, Nian-Sheng Huang, San-Yuan Yang, Yen Kuang Lu, Ru-Band |
| Description | Country affiliation: Taiwan Author Affiliation: Wu HI ( Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.) |
| Abstract | OBJECTIVES: Bipolar disorder (BP) is often comorbid with anxiety disorder (ANX), especially in bipolar II disorder (BP-II). BP patients with comorbid ANX often manifest intensified symptoms and harmful dysfunctions. However, most studies have focused on bipolar I disorder (BP-I); few have investigated the effect of comorbid ANX on the neuropsychological function of BP-II patients. We examined neuropsychological functions in BP-II patients with and without comorbid ANX. METHODS: Fifty-nine participants were recruited: 20 patients with interepisode (symptom-free) BP-II without comorbid ANX, 20 with interepisode BP-II with comorbid ANX, and 19 healthy controls. All participants were screened using the Chinese version of the Modified Schedule of Affective Disorder and Schizophrenia-Lifetime (SADS-L). Individuals comorbid with major or minor mental illness other than BP-II were excluded. Comparisons were made between the three groups using neuropsychological tests to assess memory, attention, psychomotor speed, and frontal executive function. RESULTS: BP-II patients with comorbid ANX showed poorer neuropsychological functions than those in the BP-II-only and control groups. Additionally, BP-II-only patients and controls showed equal cognitive performance. CONCLUSIONS: Because BP-II patients with comorbid ANX had the lowest scores in the majority of neuropsychological functional tests, we conclude that they have greater cognitive impairments than do BP-II patients without comorbid ANX. Neuropsychological dysfunctions seemed more strongly associated with ANX than with BP-II in interepisode periods. Identifying and managing ANX comorbidity is critical when treating BP-II patients. |
| File Format | HTM / HTML |
| ISSN | 02785846 |
| Issue Number | 8 |
| Volume Number | 35 |
| e-ISSN | 18784216 |
| Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Psychiatry Anxiety Disorders Complications Attention Physiology Bipolar Disorder Psychology Executive Function Memory Adult Female Humans Male Neuropsychological Tests Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Pharmacology |
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