NDLI: Profiles of DARPP-32 in the insular cortex with schizophrenia: a postmortem brain study.

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Profiles of DARPP-32 in the insular cortex with schizophrenia: a postmortem brain study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nishiura, Keisuke Kunii, Yasuto Wada, Akira Matsumoto, Junya Yang, Qiaohui Ikemoto, Keiko Niwa, Shin-ichi
Description	Country affiliation: Japan Author Affiliation: Nishiura K ( Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan.)
Abstract	In patients with schizophrenia, various physical disorders are sometimes discovered only when they have reached a later and more severe stage. This phenomenon is believed to be caused, at least in part, by an increase in pain threshold. The gamma-aminobutyric acid (GABA)-ergic and glutamatergic systems in the rostral agranular insular cortex (RAIC) are thought to be involved in the regulation of pain threshold. However, no postmortem studies of the cerebral cortex have previously been published. Dopamine and cAMP-regulated phosphoprotein 32 kD (DARPP-32), which is involved in the GABAergic and glutamatergic systems, is considered to be crucial for elucidating the pathogenesis of schizophrenia. Using specific antibodies, we conducted immunohistochemical examinations of the RAIC in 10 subjects from a healthy control group, and 11 subjects from a schizophrenia group. The sex, age, and postmortem interval (PMI) of the schizophrenia group were matched to those of the healthy control group. We revealed that the density of DARPP-32-immunoreactive (IR) neurons in the II and III layers of the RAIC was significantly decreased (p<0.05) in the schizophrenia group compared with the healthy control group. Our findings could partially explain the molecular basis of the pain threshold abnormalities found in patients with schizophrenia.
File Format	HTM / HTML
ISSN	02785846
Issue Number	8
Volume Number	35
e-ISSN	18784216
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Language	English
Publisher	Elsevier
Publisher Date	2011-12-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Psychiatry Cerebral Cortex Metabolism Dopamine And Camp-regulated Phosphoprotein 32 Neurons Schizophrenia Adult Aged Aged, 80 And Over Pathology Female Humans Male Middle Aged Pain Threshold Physiology Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Pharmacology

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Profiles of DARPP-32 in the insular cortex with schizophrenia: a postmortem brain study.

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Profiles of DARPP-32 in the insular cortex with schizophrenia: a postmortem brain study.