NDLI: Screening for diabetes using monitoring guidance in schizophrenia patients treated with second-generation antipsychotics: a 1-year follow-up study.

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Screening for diabetes using monitoring guidance in schizophrenia patients treated with second-generation antipsychotics: a 1-year follow-up study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kusumi, Ichiro Ito, Koki Uemura, Keiichi Honda, Minoru Hayashishita, Tadayuki Miyamoto, Kazuko Sawayama, Hiroyuki Kako, Yuki Tsuchida, Shoichiro Hashimoto, Naoki Koyama, Tsukasa
Description	Country affiliation: Japan Author Affiliation: Kusumi I ( Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan. ikusumi@med.hokudai.ac.jp)
Abstract	Second-generation antipsychotics (SGAs) tend to induce weight gain, dyslipidemia and diabetes mellitus. For those reasons, patients treated with SGAs should receive appropriate monitoring to avoid morbidity and mortality associated with cardiovascular disease. We conducted a one-year follow-up study using Japanese blood glucose monitoring guidance in schizophrenia patients treated with SGAs to evaluate the detection capability of the guidance in real clinical settings and to assess the importance of longitudinal monitoring. This retrospective cohort study included schizophrenia patients receiving at least one SGA, who were enrolled during June 2008-January 2009 at multiple sites and who had both baseline data and follow-up monitoring data at month 12. After one-year follow-up, the probable diabetes type (fasting blood glucose is higher than 125 mg/dL, casual blood glucose is higher than 179 mg/dL, or glycosylated hemoglobin (Hb(A1c)) is greater than 6.4%) was detected in 30 (8%) of the patients, and the pre-diabetes type (fasting blood glucose is 110-125 mg/dL, or casual blood glucose is 140-179 mg/dL, or Hb(A1c) is 6.0-6.4%) in 65 (17.4%) out of the total of 374 patients. During the follow-up period, 1.5% of patients had advanced from the normal (fasting blood glucose is less than 110 mg/dL, casual blood glucose is less than 140 mg/dL, or Hb(A1c) is less than 6.0%) to probable diabetes type and 42.4% had progressed from the pre-diabetes to probable diabetes type. Predictive factors for worsening of the diabetic state were a family history of diabetes, and high serum total-cholesterol and triglyceride levels at baseline. Not only cross-sectional baseline screening but also longitudinal follow-up screening is important to detect glucose abnormalities in patients treated with SGAs.
File Format	HTM / HTML
ISSN	02785846
Issue Number	8
Volume Number	35
e-ISSN	18784216
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Language	English
Publisher	Elsevier
Publisher Date	2011-12-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Psychiatry Antipsychotic Agents Adverse Effects Diabetes Mellitus, Type 2 Diagnosis Adult Aged Therapeutic Use Blood Glucose Chemically Induced Female Follow-up Studies Humans Male Middle Aged Retrospective Studies Schizophrenia Drug Therapy Journal Article Multicenter Study
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Pharmacology

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