NDLI: Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine.

Please wait, while we are loading the content...

Year: 2017 Volume: 27

Year: 2017 Volume: 26

Year: 2017 Volume: 25

Year: 2017 Volume: 24

Year: 2016 Volume: 23

Year: 2015 Volume: 22

Year: 2014 Volume: 21

Year: 2013 Volume: 21

Year: 2013 Volume: 20

Year: 2012 Volume: 20

Year: 2012 Volume: 19

Year: 2012 Volume: 19 Issue: 14

Year: 2012 Volume: 19 Issue: 13

Year: 2012 Volume: 19 Issue: 12

Year: 2012 Volume: 19 Issue: 11

Year: 2012 Volume: 19 Issue: 10

Year: 2012 Volume: 19 Issue: 7

Year: 2012 Volume: 19 Issue: 6

Year: 2012 Volume: 19 Issue: 5

Year: 2012 Volume: 19 Issue: 2

Year: 2012 Volume: 19 Issue: 3-4

Pharmacokinetic, tissue distribution and excretion of ginsenoside-Rd in rodents.

Assessment of anxiolytic and panicolytic effects of dichloromethane fraction from stems of Kielmeyera coriacea.

Effect of loganin on experimental diabetic nephropathy.

Salidroside inhibits migration and invasion of human fibrosarcoma HT1080 cells.

Neuroprotective iridoid glycosides from Cornus officinalis fruits against glutamate-induced toxicity in HT22 hippocampal cells.

Bioactive components in the fruits of Ziziphus jujuba Mill. against the inflammatory irritant action of Euphorbia plants.

Anti-metastatic effects of ginsenoside Rd via inactivation of MAPK signaling and induction of focal adhesion formation.

Contribution of flavonoids and catechol to the reduction of ICAM-1 expression in endothelial cells by a standardised Willow bark extract.

Antitumor activity of Pulsatilla chinensis (Bunge) Regel saponins in human liver tumor 7402 cells in vitro and in vivo.

Potential anticancer activity of young Carpinus betulus leaves.

Effects of ethanolic extract from Radix Scrophulariae on ventricular remodeling in rats.

Tanshinone IIA and tanshinone I production by Trichoderma atroviride D16, an endophytic fungus in Salvia miltiorrhiza.

Investigation of cytochrome P450 1A2 and 3A inhibitory properties of Danshen tincture.

European regulation of herbal medicinal products on the border area to the food sector.

Psychopharmacological profile of Chamomile (Matricaria recutita L.) essential oil in mice.

Antihyperglycemic effect of iridoid glucoside, isolated from the leaves of Vitex negundo in streptozotocin-induced diabetic rats with special reference to glycoprotein components.

Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity.

Bioactive metabolites from Chaetomium globosum L18, an endophytic fungus in the medicinal plant Curcuma wenyujin.

GABA(A) receptor modulators from Chinese herbal medicines traditionally applied against insomnia and anxiety.

In vitro interaction of usnic acid in combination with antimicrobial agents against methicillin-resistant Staphylococcus aureus clinical isolates determined by FICI and ΔE model methods.

Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine.

Effects of Euterpe oleracea Mart. (AÇAÍ) extract in acute lung inflammation induced by cigarette smoke in the mouse.

Berberine alleviates ischemic arrhythmias via recovering depressed I(to) and I(Ca) currents in diabetic rats.

In vitro anti-viral effect of ß-santalol against influenza viral replication.

Synergistic activity of coriander oil and conventional antibiotics against Acinetobacter baumannii.

Bioassay-guided isolation of an alkaloid with antiangiogenic and antitumor activities from the extract of Fissistigma cavaleriei root.

Suppression of matrix metalloproteinase-9 expression by andrographolide in human monocytic THP-1 cells via inhibition of NF-κB activation.

Synergism of plant-derived polyphenols in adipogenesis: perspectives and implications.

Effects of (-) mammea A/BB isolated from Calophyllum brasiliense leaves and derivatives on mitochondrial membrane of Leishmania amazonensis.

Year: 2012 Volume: 19 Issue: 8-9

Year: 2011 Volume: 19

Year: 2011 Volume: 18

Year: 2010 Volume: 18

Year: 2010 Volume: 17

Year: 2009 Volume: 16

Year: 2008 Volume: 15

Year: 2006 Volume: 13

Year: 1998 Volume: 5

Year: 1997 Volume: 4

Year: 1997 Volume: 3

Year: 1996 Volume: 3

Year: 1996 Volume: 2

Year: 1995 Volume: 2

Year: 1995 Volume: 1

Year: 1994 Volume: 1

Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ulrich-Merzenich, G. Koptina, A. Kelber, O. Freischmidt, A. Heilmann, J. Müller, J. Sadeghlar, F. Zeitler, H. Wagner, H.
Description	Country affiliation: Germany Author Affiliation: Ulrich-Merzenich G ( Medical Clinic III, Universitätsklinikum, Rheinische Friedrich-Wilhelms-University Bonn, D-53111 Bonn, Germany. gudrun.ulrich-merzenich@ukb.uni-bonn.de)
Abstract	BACKGROUND AND OBJECTIVE: Gene expression profiles of Sprague-Dawley (SD) rats treated with a standardized willow bark extract (WB), its salicin rich ethanol fraction (EtOH-FR) or the tricyclic antidepressant imipramine were evaluated for their potential to induce adverse events. Treatments had shown antidepressant-like effects. METHODS: Gene expression profiles (Agilent Whole Genome Array, n=4/group) obtained from the peripheral blood of male SD rats treated with WB (STW 33-I), EtOH-FR (30 mg/kg bw) or imipramine (20 mg/kg bw) were analysed comparatively by the Ingenuity Systems Programme, which allows to conduct model calculations of thresholds for theoretical potential adverse events (AE). RESULTS: The number of genes regulated by the three treatments were 1673 (WB), 117 (EtOH-FR) and 1733 (imipramine). The three treatments related to 47 disease clusters. The WB extract reached the threshold for a potential AE in one disease cluster (cardiac hypertrophy), whereas the EtOH-FR exceeded the threshold in 5 disease clusters (cardiac arteriopathy and stenosis, glomerular injury, pulmonary hypertension, alkaline phosphatase levels â). Imipramine treatment hit 13 disease clusters: tachycardia, palpitation, myocardial infarction, arrhythmias, heart block, precipitation of congestive heart failure; urinary retention, altered liver functions. Those correspond to known potential adverse events. Glomerular injury and altered liver functions are part of the side effect profile of salicylic acid derivatives in agreement with the findings for the salicin rich EtOH-FR. CONCLUSION: There is no linear relationship between the number of constituents of a drug (preparation) and the number of different targets hit in a biological system on the gene expression level. Therefore, the number of genetic targets in a biological system does not necessarily increase with the complexity of the treatment corresponding to the non-linear behaviour of biological systems. Regarding gene expression levels AE of single treatments are not necessarily additive in combination treatments. The applied method appears to be an interesting screening tool for the prediction of potential AE. The phenomena that imipramine crossed the potential threshold for AEs several times whereas the WB extract did reach the threshold level only once, however not backed by clinical data for this AE, deserves to be further investigated. It questions the commonly assumed principle that substances with low number or without AE will have a poor efficacy.
File Format	HTM / HTML
ISSN	09447113
Issue Number	3-4
Volume Number	19
e-ISSN	1618095X
Journal	Phytomedicine
Language	English
Publisher	Elsevier
Publisher Date	2012-02-15
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Complementary Therapies Antidepressive Agents, Tricyclic Adverse Effects Gene Expression Profiling Methods Heart Diseases Chemically Induced Imipramine Salicylates Animals Chemistry Benzyl Alcohols Drug-induced Liver Injury Drug Therapy Pathology Ethanol Gene Expression Regulation Drug Effects Glucosides Hypertension, Pulmonary Male Nephritis Phytotherapy Plant Bark Plant Extracts Rats Rats, Sprague-dawley Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in