NDLI: Antidepressant-Like Effects of Sanggenon G, Isolated from the Root Bark of Morus alba, in Rats: Involvement of the Serotonergic System.

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Antidepressant-Like Effects of Sanggenon G, Isolated from the Root Bark of Morus alba, in Rats: Involvement of the Serotonergic System.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lim, Dong Wook Jung, Jae-Woo Park, Ji-Hae Baek, Nam-In Kim, Yun Tai Kim, In-Ho Han, Daeseok
Description	Author Affiliation: Lim DW ( Research Group of Innovative Special Food, Korea Food Research Institute.)
Abstract	The root bark of Morus alba is commonly used as an alternative medicine due to its numerous health benefits in humans. However, the antidepressant effects of various active components from M. alba have not been fully elucidated. In this study, we aimed to determine whether sanggenon G, an active compound isolated from the root bark of M. alba, exhibited antidepressant-like activity in rats subjected to forced swim test (FST)-induced depression. Acute treatment of rats with sanggenon G (30 mg/kg, intraperitoneally (i.p.)) significantly reduced immobility time and increased swimming time without any significant change in climbing. Rats treated with sanggenon G also exhibited a decrease in the limbic hypothalamic-pituitary-adrenal (HPA) axis response to the FST, as indicated by attenuation of the corticosterone response and decreased c-Fos immunoreactivity in the hypothalamic paraventricular nucleus (PVN). In addition, the antidepressant-like effects of sanggenon G were significantly inhibited by WAY100635 (1 mg/kg, i.p.; a selective 5-hydroxytryptamine1A (5-HT1A) receptor antagonist), but not SCH23390 (0.05 mg/kg, i.p.; a dopamine D1 receptor antagonist). Our findings suggested that the antidepressant-like effects of sanggenon G were mediated by an interaction with the serotonergic system. Further studies are needed to evaluate the potential of sanggenon G as an alternative therapeutic approach for the treatment of depression.
File Format	HTM / HTML
ISSN	09186158
e-ISSN	13475215
Journal	Biological & Pharmaceutical Bulletin
Issue Number	11
Volume Number	38
Language	English
Publisher	The Pharmaceutical Society of Japan J-STAGE
Publisher Date	2015-01-01
Publisher Place	Japan
Access Restriction	Open
Subject Keyword	Discipline Biochemistry Discipline Pharmacology Antidepressive Agents Therapeutic Use Benzofurans Chromones Depression Drug Therapy Morus Chemistry Phytotherapy Plant Extracts Serotonin Agents Animals Pharmacology Corticosterone Metabolism Hypothalamo-hypophyseal System Drug Effects Paraventricular Hypothalamic Nucleus Pituitary-adrenal System Plant Bark Plant Roots Proto-oncogene Proteins C-fos Rats, Sprague-dawley Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmacology Pharmaceutical Science

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