NDLI: Contribution of flavonoids and catechol to the reduction of ICAM-1 expression in endothelial cells by a standardised Willow bark extract.

Please wait, while we are loading the content...

Antihyperglycemic effect of iridoid glucoside, isolated from the leaves of Vitex negundo in streptozotocin-induced diabetic rats with special reference to glycoprotein components.

Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity.

Bioactive metabolites from Chaetomium globosum L18, an endophytic fungus in the medicinal plant Curcuma wenyujin.

GABA(A) receptor modulators from Chinese herbal medicines traditionally applied against insomnia and anxiety.

In vitro interaction of usnic acid in combination with antimicrobial agents against methicillin-resistant Staphylococcus aureus clinical isolates determined by FICI and ΔE model methods.

Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine.

Effects of Euterpe oleracea Mart. (AÇAÍ) extract in acute lung inflammation induced by cigarette smoke in the mouse.

Berberine alleviates ischemic arrhythmias via recovering depressed I(to) and I(Ca) currents in diabetic rats.

In vitro anti-viral effect of ß-santalol against influenza viral replication.

Synergistic activity of coriander oil and conventional antibiotics against Acinetobacter baumannii.

Bioassay-guided isolation of an alkaloid with antiangiogenic and antitumor activities from the extract of Fissistigma cavaleriei root.

Suppression of matrix metalloproteinase-9 expression by andrographolide in human monocytic THP-1 cells via inhibition of NF-κB activation.

Synergism of plant-derived polyphenols in adipogenesis: perspectives and implications.

Effects of (-) mammea A/BB isolated from Calophyllum brasiliense leaves and derivatives on mitochondrial membrane of Leishmania amazonensis.

Year: 2012 Volume: 19 Issue: 8-9

Year: 2011 Volume: 19

Year: 2011 Volume: 18

Year: 2010 Volume: 18

Year: 2010 Volume: 17

Year: 2009 Volume: 16

Year: 2008 Volume: 15

Year: 2006 Volume: 13

Contribution of flavonoids and catechol to the reduction of ICAM-1 expression in endothelial cells by a standardised Willow bark extract.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Freischmidt, A. Jürgenliemk, G. Kraus, B. Okpanyi, S. N. Müller, J. Kelber, O. Weiser, D. Heilmann, J.
Description	Country affiliation: Germany Author Affiliation: Freischmidt A ( Lehrstuhl für Pharmazeutische Biologie, Universität Regensburg, 93040 Regensburg, Germany.)
Abstract	INTRODUCTION: A quantified aqueous Willow bark extract (STW 33-I) was tested concerning its inhibitory activity on TNF- induced ICAM-1 expression in human microvascular endothelial cells (HMEC-1) and further fractionated to isolate the active compounds. RESULTS: At 50 µg/ml the extract, which had been prepared from Salix purpurea L., decreased ICAM-1 expression to 40% compared to control cells without showing cytotoxic effects. Further liquid-liquid partition revealed an ethyl acetate phase with potent reduction of ICAM-1 expression to 40% at 8 µg/ml. This fraction was comprehensively characterised by the isolation of flavanone aglyca and their corresponding glycosides, chalcone glycosides, salicin derivatives, cyclohexane-1,2-diol glycosides, catechol and trans-p-coumaric acid. All compounds were investigated for their activity on TNF- induced ICAM-1 expression. The flavonoid and chalcone glycosides were not active up to 50 µM, whereas catechol and eriodictyol at the same concentration showed a significant reduction of ICAM-1 expression to 50% of control. Interestingly, other isolated flavanone aglyca like taxifolin, dihydrokaempferol and naringenin showed only weak or moderate inhibitory activity. Eriodictyol was a minor compound in the extract, whereas the catechol content in the extract (without excipients) reached 2.3%, determined by HPLC. One of the isolated cyclohexan-1,2-diol glucosides, 6'-O-4-hydroxybenzoyl-grandidentin, is a new natural compound. CONCLUSION: As catechol is quantitatively important in Willow bark extracts it can be concluded from the in vitro data that not only flavonoids and salicin derivatives, but also catechol can probably contribute to the anti-inflammatory activity of Willow bark extracts.
File Format	HTM / HTML
ISSN	09447113
Issue Number	3-4
Volume Number	19
e-ISSN	1618095X
Journal	Phytomedicine
Language	English
Publisher	Elsevier
Publisher Date	2012-02-15
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Complementary Therapies Catechols Pharmacology Endothelial Cells Drug Effects Flavonoids Intercellular Adhesion Molecule-1 Metabolism Plant Bark Chemistry Plant Extracts Acetates Anti-inflammatory Agents Isolation & Purification Cell Survival Chemical Fractionation Instrumentation Methods Chromatography, High Pressure Liquid Coumaric Acids Flavanones Humans Molecular Structure Quercetin Analogs & Derivatives Salix Tumor Necrosis Factor-alpha Adverse Effects Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Catechol, a bioactive degradation product of salicortin, reduces TNF- induced ICAM-1 expression in human endothelial cells.

Identification of Salicylates in Willow Bark (Salix Cortex) for Targeting Peripheral Inflammation

Anti-inflammatory effects of the willow bark extract STW 33-I (Proaktiv(®)) in LPS-activated human monocytes and differentiated macrophages.

Drug-Drug Interaction Potential, Cytotoxicity, and Reactive Oxygen Species Production of Salix Cortex Extracts Using Human Hepatocyte-Like HepaRG Cells

Willow bark extract (Salicis cortex) for gonarthrosis and coxarthrosis--results of a cohort study with a control group.

Effects of Pinus brutia bark extract and Pycnogenol in a rat model of carrageenan induced inflammation.

Identification and characterization of three new flavonoids from Rhododendron dauricum.

Facilitated cellular uptake and suppression of inducible nitric oxide synthase by a metabolite of maritime pine bark extract (Pycnogenol).

The vasodilating effect of a Hintonia latiflora extract with antidiabetic action.

Contribution of flavonoids and catechol to the reduction of ICAM-1 expression in endothelial cells by a standardised Willow bark extract.

Similar Documents

Catechol, a bioactive degradation product of salicortin, reduces TNF- induced ICAM-1 expression in human endothelial cells.

Identification of Salicylates in Willow Bark (Salix Cortex) for Targeting Peripheral Inflammation

Anti-inflammatory effects of the willow bark extract STW 33-I (Proaktiv(®)) in LPS-activated human monocytes and differentiated macrophages.

Drug-Drug Interaction Potential, Cytotoxicity, and Reactive Oxygen Species Production of Salix Cortex Extracts Using Human Hepatocyte-Like HepaRG Cells

Willow bark extract (Salicis cortex) for gonarthrosis and coxarthrosis--results of a cohort study with a control group.

Effects of Pinus brutia bark extract and Pycnogenol in a rat model of carrageenan induced inflammation.

Identification and characterization of three new flavonoids from Rhododendron dauricum.

Facilitated cellular uptake and suppression of inducible nitric oxide synthase by a metabolite of maritime pine bark extract (Pycnogenol).

The vasodilating effect of a Hintonia latiflora extract with antidiabetic action.

Contribution of flavonoids and catechol to the reduction of ICAM-1 expression in endothelial cells by a standardised Willow bark extract.