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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Staurengo-Ferrari, Larissa Mizokami, Sandra S. Silva, Jean J. da Silva, Francisco O. N. Sousa, Eduardo H. S. da França, Luiz G. Matuoka, Mariana L. Georgetti, Sandra R. Baracat, Marcela M. Casagrande, Rubia Pavanelli, Wander R. Verri, Waldiceu A. |
| Description | Country affiliation: Brazil Author Affiliation: Staurengo-Ferrari L ( Departamento de Patologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid KM480 PR445, CEP 86051-990, Cx Postal 6001, Londrina, Paraná, Brazil.) |
| Abstract | The activation of nitric oxide (NO) production is an analgesic mechanism shared by drugs such as morphine and diclofenac. Therefore, the controlled release of low amounts of NO seems to be a promising analgesic approach. In the present study, the antinociceptive effect of the ruthenium NO donor [Ru(bpy)2(NO)SO3](PF6) (complex I) was investigated. It was observed that complex I inhibited in a dose (0.3-10mg/kg)-dependent manner the acetic acid-induced writhing response. At the dose of 1mg/kg, complex I inhibited the phenyl-p-benzoquinone-induced writhing response and formalin- and complete Freund's adjuvant-induced licking and flinch responses. Additionally, complex I also inhibited transient receptor potential cation channel subfamily V member 1 (TRPV1)-dependent overt pain-like behavior induced by capsaicin. Complex I also inhibited the carrageenin-induced mechanical hyperalgesia and increase of myeloperoxidase activity (MPO) in paw skin samples. The inhibitory effect of complex I in the carrageenin-induced hyperalgesia, MPO activity and formalin was prevented by the treatment with ODQ, KT5823 and glybenclamide, indicating that complex I inhibits inflammatory hyperalgesia by activating the cGMP/PKG/ATP-sensitive potassium channel signaling pathway. The present study demonstrates the efficacy of a novel ruthenium NO donor and its analgesic mechanisms. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Volume Number | 105 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-04-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Inflammation Prevention & Control Nitric Oxide Donors Pharmacology Pain Potassium Channels Metabolism Ruthenium Compounds Signal Transduction Trpv Cation Channels Physiology Adenosine Triphosphate Animals Cyclic Gmp Cyclic Gmp-dependent Protein Kinases Electron Transport Complex I Mice Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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