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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Prathab Balaji, S. Vijay Chand, C. Justin, A. Ramanathan, M. |
| Description | Country affiliation: India Author Affiliation: Prathab Balaji S ( Department of Pharmacology, PSG College of Pharmacy, Peelamedu, Coimbatore, TN 641004, India.); Vijay Chand C ( Department of Pharmacology, PSG College of Pharmacy, Peelamedu, Coimbatore, TN 641004, India.); Justin A ( Department of Pharmacology, PSG College of Pharmacy, Peelamedu, Coimbatore, TN 641004, India.); Ramanathan M ( Department of Pharmacology, PSG College of Pharmacy, Peelamedu, Coimbatore, TN 641004, India. Electronic address: muthiah.in@gmail.com.) |
| Abstract | Telmisartan (TM), an angiotensin II receptor I (AT1) blocker, has been reported to have agonist property with respect to PPAR-γ. Activation of PPAR-γ receptor by TM attenuated the lipopolysaccharide (LPS) mediated TLR4 central downstream inflammatory responses. However, the missing link between PPAR-γ and TLR4 signaling with TM stimulation has not been clarified. Hence, the present study has been designed to evaluate the molecular mechanism involving PPARγ-TLR4 signaling with TM stimulation in LPS induced inflammatory model. LPS was administered in rats through ICV and the rats were treated with either PPAR-γ antagonist GW9662 (GW) or TM or both. After 14days of LPS administration, the rats were subjected to behavioral tests and their brains were isolated for blotting techniques. The protein study includes NF-κB, PPAR-γ receptors, and their downstream proteins (MyD88 & SARM). The pro-inflammatory cytokines (TNF- , IL-1ß, IL-6) levels were measured by ELISA and cresyl violet staining in the hippocampus region to measure the neuroprotective activity. Results have shown that TM significantly increased the motor co-ordination, cognitive functions, and activated SARM and PPAR-γ protein levels. Also, TM treatment decreased the NF-κB, MyD88 activation, and cytokines release in LPS rats. The co-administration of GW attenuated the TM responses in the parameters studied except cognitive functions. TM (10mg/kg) has significantly reduced the LPS mediated inflammatory responses. This resulted in effective regeneration of hippocampal neurons as observed by cresyl violet staining. It can be concluded that the activation of PPAR-γ receptors may increase the SARM and decrease the MyD88 and NF-κB expression. This negative regulation of SARM dependent inflammation control could be a possible mechanism for TM anti-neuroinflammatory activity. This study of TM in neuro-inflammatory model may further confirm the dual activities of TM that controls hypertension and cognition through AT1 blockade and also attenuates neuro-inflammation via PPAR-γ agonistic property. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Volume Number | 137 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-10-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Anti-inflammatory Agents Pharmacology Armadillo Domain Proteins Biosynthesis Benzimidazoles Benzoates Cognition Drug Effects Cytoskeletal Proteins Myeloid Differentiation Factor 88 Ppar Gamma Agonists Signal Transduction Animals Therapeutic Use Physiology Inflammation Drug Therapy Metabolism Male Maze Learning Rats Rats, Sprague-dawley Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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