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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Maple, Amanda M. Smith, Katherine J. Perna, Marla K. Brown, Russell W. |
| Description | Country affiliation: United States Author Affiliation: Maple AM ( Department of Basic Medical Sciences, The University of Arizona College of Medicine - Phoenix, 550 E. Van Buren St., Phoenix, AZ 85004, United States.); Smith KJ ( Department of Psychology, East Tennessee State University, P. O. Box 70649, Johnson City, TN 37614, United States.); Perna MK ( Department of Psychology, East Tennessee State University, P. O. Box 70649, Johnson City, TN 37614, United States.); Brown RW ( Department of Psychology, East Tennessee State University, P. O. Box 70649, Johnson City, TN 37614, United States. Electronic address: brown1@mail.etsu.edu.) |
| Abstract | We have shown that repeated neonatal quinpirole (QUIN; a dopamine D2-like receptor agonist) treatment in rats produces long-lasting supersensitization of dopamine D2 receptors that persists into adulthood but without producing a change in receptor number. The current study was designed to analyze the effects of neonatal QUIN on auditory sensorimotor gating as measured through prepulse inhibition (PPI). Male and female Sprague-Dawley rats were neonatally treated with QUIN (1mg/kg) or saline from postnatal days (P)1-21. At P60, the number of yawns was recorded for a 1h period in response to an acute QUIN (1mg/kg) injection as yawning is a D2-like receptor mediated behavioral event. Five days later, rats began (PPI) behavioral testing in two phases. In phase I, three different prepulse intensities (73, 76, and 82dB) were administered 100-ms before a 115dB pulse on 10 consecutive days. In phase II, three different interstimulus intervals (ISI; 50, 100, and 150ms) were inserted between the 73 or 76dB prepulse and 115dB pulse over 10 consecutive days of testing. A PPI probe trial was administered at the end of each phase after an acute 100µg/kgi.p. injection of QUIN to all animals. Replicating previous work, neonatal QUIN enhanced yawning compared to controls, verifying D2 receptor supersensitization. Regarding PPI, neonatal QUIN resulted in deficits across both phases of testing persistent across all testing days. Probe trial results revealed that acute QUIN treatment resulted in more robust PPI deficits in neonatal QUIN animals, although this deficit was related to prepulse intensity and ISI. These findings provide evidence that neonatal QUIN treatment results in deficits of auditory sensorimotor gating in adulthood as measured through PPI. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Volume Number | 137 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-10-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Dopamine Agonists Toxicity Prepulse Inhibition Drug Effects Quinpirole Sensory Gating Yawning Acoustic Stimulation Methods Age Factors Animals Animals, Newborn Female Male Physiology Rats Rats, Sprague-dawley Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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